Age specific changes in BMI and BMI distribution among Australian adults using cross-sectional surveys from 1980 to 2008

Hayes, Alison; Gearon, Emma; Backholer, Kathryn; Baumann, Anette; Peeters, Anna

doi:10.1016/j.orcp.2014.10.077

Cited by 10 publications

(13 citation statements)

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“…At present, the Chinese standard BMI cut-off points are ≥24 kg/m 2 for overweight and ≥ 28 kg/m 2 for obesity. It has been reported that the thresholds of BMI may be different by age group [23]. In this study, patients were divided into two groups to rule out the effect of age.…”

Section: Discussionmentioning

confidence: 99%

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

Pan

Yao

et al. 2020

BMC Infect Dis

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Background: The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data obtained during therapeutic drug monitoring. Methods: This retrospective study used data collected from January 2017 to January 2019. Adult patients (n = 204) received vancomycin treatment at a dose of 1000 mg every 12 h and underwent serum monitoring. Data collected included patient disease category, sex, age, height, weight, vancomycin concentrations, and serum creatinine. The CrCl values were estimated using the Cockcroft-Gault formula. In this study, statistical comparisons were performed on the results of patients according to serum vancomycin concentration. Results: Serum vancomycin concentration was significantly related to BMI (P < 0.001) and CrCl (P < 0.05) in adult patients. Furthermore, the trough serum vancomycin concentration showed a logarithmic correlation with BMI (R = − 0.5108, 95% CI: − 0.6082 to − 0.3982, P < 0.001) and CrCl (R = − 0.5739, 95% CI: − 0.6616 to − 0.4707, P < 0.001). The multivariate analysis showed that BMI and CrCl are independent contributors to the trough vancomycin concentration. Moreover, some of the patients with higher BMI (≥ 24 kg/m 2) met the goal trough concentration after an adjustment from 1000 mg every 12 h to 1000 mg every 8 h. Conclusions: Serum vancomycin concentration decreases progressively with increasing BMI and the augmentation in CrCl in adult patients. The trough concentration of vancomycin should be continuously monitored for patients with a BMI ≥ 24 kg/m 2 , and the dosage regimen should be adjusted to reach the target trough concentration in these patients to reduce the impact of BMI.

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Section: Discussionmentioning

confidence: 99%

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

Pan

Yao

et al. 2020

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…At present, the Chinese standard BMI cut-off points are ≥ 24 kg/m 2 for overweight and ≥ 28 kg/m 2 for obesity. It has been reported that the thresholds of BMI may be different by age group [21]. In this study, patients were divided into two groups to rule out the effect of age.…”

Section: Discussionmentioning

confidence: 99%

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

Pan

Yao

et al. 2020

Preprint

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Background: The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data obtained during therapeutic drug monitoring.Methods: This retrospective study used data collected from January 2017 to January 2019. Adult patients (n=204) received vancomycin treatment at a dose of 1000 mg every 12 h and underwent serum monitoring. Data collected included patient disease category, sex, age, height, weight, vancomycin regimens and concentrations, and serum creatinine. In this study, statistical comparisons were performed on the results of patients according to serum vancomycin concentration.Results: Serum vancomycin concentration was significantly related to BMI (P < 0.001) and CrCl (P < 0.05) in adult patients. Furthermore, the trough serum vancomycin concentration showed a logarithmic correlation with BMI (R = -0.5108, 95% CI: -0.6082 to -0.3982, P < 0.001) and CrCl (R = -0.5739, 95% CI: -0.6616 to -0.4707, P < 0.001). In addition, CrCl was significantly related to BMI (P < 0.01). Moreover, some of the patients with higher BMI (≥ 24 kg/m2) met the goal trough concentration after an adjustment from 1000 mg every 12 h to 1000 mg every 8 h.Conclusions: Serum vancomycin concentration decreases progressively with increasing BMI due to the augmentation in CrCl in adult patients. Therefore, the trough concentration of vancomycin should be continuously monitored for patients with a BMI ≥ 24 kg/m2 while considering the patient CrCl. The dosage regimen should be adjusted in a timely manner to reach the target trough concentration and reduce the impact of BMI.

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“…BMI is used routinely in adults >20 years of age as an indirect measure of overall adiposity. BMI increases dramatically from young adulthood to middle-age, is greatest in middle-age, and decreases in old age 24 , 25 . Except for the youngest and oldest age-classes, men have higher BMI than women, but the decline in BMI at old age is greater for women 24 .…”

Section: Discussionmentioning

confidence: 99%

Genetic Architecture of Human Obesity Traits in the Rhesus Macaque

Raboin

Letaw

Mitchell

et al. 2019

Obesity

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Objective: While the metabolic consequences of obesity have been studied extensively in the rhesus macaque, corollary genetic studies of obesity are non-existent. Here, we assess genetic contributions to spontaneous adiposity in this species. Methods: We assessed phenotypic variation by age-class and sex for body mass index, waist-to-height ratio, waist-to-thigh ratio, and waist circumference in 583 macaques. We estimated total and sex-specific heritability for all traits, including waist-to-thigh ratio adjusted for BMI, as well as genotypic and phenotypic correlations. We also assessed functional genetic variation at BDNF , FTO , LEP , LEPR , MC4R , PCSK1 , POMC , and SIM1 in 4 animals with extreme spontaneous adiposity. Results: Trait heritability in the combined sample was low-to-moderate (0.14–0.32), while sex-specific heritability was more substantial (0.20–0.67). Heritability was greater in females for all traits except BMI. All traits were robustly correlated, with genetic correlations of 0.63–0.93 indicating substantial pleiotropy. We discovered likely functional variants in the 4 macaques at all 8 human obesity genes, including 6 missense mutations in BDNF , FTO , LEP , LEPR , and PCSK1 , and notably, 1 nonsense mutation in LEPR . Conclusions: We find a moderate polygenic contribution to adiposity in rhesus macaques, and mutations with potentially larger effects in multiple genes that influence obesity in humans.

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Age specific changes in BMI and BMI distribution among Australian adults using cross-sectional surveys from 1980 to 2008

Cited by 10 publications

References 0 publications

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

The effect of body mass index and creatinine clearance on serum trough concentration of vancomycin in adult patients

Genetic Architecture of Human Obesity Traits in the Rhesus Macaque

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