Age-Specific Features of Hypoxia Tolerance and Intensity of Lipopolysaccharide-Induced Systemic Inflammatory Response in Wistar Rats

Косырева, А. М.; Джалилова, Д. Ш.; Цветков, И.С.; Diatroptov, M. E.; Makarova, Olga

doi:10.1007/s10517-019-04421-3

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…It has been observed that submaximal exercise performance changed during acute exposure to HA [ 14 ], and the reduction in submaximal exercise capacity is associated with a decrease in arterial oxygen content as a result of the reduction in the inspired partial pressure of oxygen [ 2 ] partly compensated by increases in cardiac output and in local muscle blood flow [ 14 , 15 ]. In fact, in our study, we found an increment on HR at HA compared to SL before and after the test and during the recovery period.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, experimental studies in prepubertal male rats showed the smallest tolerance to hypoxia correlated with inflammatory diseases [ 15 ]. Indeed, a recent review has shown that the hypoxia-inducible factor (HIF)-1 expression levels’ variability, determined by age, gender, ethnicity and others, could predispose the individual in terms of tolerance and adaptation to hypoxia and development of certain infectious inflammatory and tumor processes [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Physiological Responses at Rest and Exercise to High Altitude in Lowland Children and Adolescents

Lang

Vizcaíno-Muñoz

Jopia³

et al. 2021

Life

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During the last decades, the number of lowland children exposed to high altitude (HA) has increased drastically. Several factors may influence the development of illness after acute HA exposure on children and adolescent populations, such as altitude reached, ascent velocity, time spent at altitude and, especially, their age. The main goal of this study was to evaluate the resting cardiorespiratory physiological and submaximal exercise responses under natural HA conditions by means of the six-minute walking test (six MWT). Secondly, we aimed to identify the signs and symptoms associated with acute mountain sickness (AMS) onset after acute HA exposure in children and adolescents. Forty-two children and adolescents, 18 boys and 24 girls aged from 11 to 15 years old, participated in this study, which was performed at sea level (SL) and during the first 42 hours at HA (3330 m). The Lake Louise score (LLS) was recorded in order to evaluate the evolution of AMS symptoms. Submaximal exercise tests (six MWT) were performed at SL and HA. Physiological parameters such as heart rate, systolic and diastolic blood pressure, respiratory rate and arterialized oxygen saturation were measured at rest and after ending exercise testing at the two altitudes. After acute HA exposure, the participants showed lower arterial oxygen saturation levels at rest and after the submaximal test compared to SL (p < 0.001). Resting heart rate, respiratory rate and diastolic blood pressure presented higher values at HA (p < 0.01). Moreover, heart rate, diastolic blood pressure and dyspnea values increased before, during and after exercise at HA (p < 0.01). Moreover, submaximal exercise performance decreased at HA (p < 0.001). The AMS incidence at HA ranged from 9.5% to 19%, with mild to moderate symptoms. In conclusion, acute HA exposure in children and adolescent individuals produces an increase in basal cardiorespiratory parameters and a decrement in arterial oxygen saturation. Moreover, cardiorespiratory parameters increase during submaximal exercise at HA. Mild to moderate symptoms of AMS at 3330 m and adequate cardiovascular responses to submaximal exercise do not contraindicate the ascension of children and adolescents to that altitude, at least for a limited period of time.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physiological Responses at Rest and Exercise to High Altitude in Lowland Children and Adolescents

Lang

Vizcaíno-Muñoz

Jopia³

et al. 2021

Life

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“…In comparison to males, female rats are more tolerant to hypoxia: among female rats, tolerant-to-hypoxia organisms prevail, while males are predominantly susceptible and normal. We have identified sex differences in the morphological and functional state of the immune system, depending on hypoxia tolerance [ 200 , 204 ].…”

Section: Physiological Biochemical and Molecular-biological Charmentioning

confidence: 99%

“…This could be possible due to the physiological immaturity of the nervous and endocrine systems, and the associated low oxygen consumption. We found that, in comparison to newborn and adult animals, prepubertal Wistar rats have the least tolerance to hypoxia, which correlates with the most pronounced manifestations of the systemic inflammatory response [ 204 ].…”

Section: Physiological Biochemical and Molecular-biological Charmentioning

confidence: 99%

Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

Джалилова

Makarova

2020

Biomedicines

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Hypoxia plays an important role in the development of many infectious, inflammatory, and tumor diseases. The predisposition to such disorders is mostly provided by differences in basic tolerance to oxygen deficiency, which we discuss in this review. Except the direct exposure of different-severity hypoxia in decompression chambers or in highland conditions, there are no alternative methods for determining organism tolerance. Due to the variability of the detection methods, differences in many parameters between tolerant and susceptible organisms are still not well-characterized, but some of them can serve as biomarkers of susceptibility to hypoxia. At the moment, several potential biomarkers in conditions after hypoxic exposure have been identified both in experimental animals and humans. The main potential biomarkers are Hypoxia-Inducible Factor (HIF)-1, Heat-Shock Protein 70 (HSP70), and NO. Due to the different mechanisms of various high-altitude diseases, biomarkers may not be highly specific and universal. Therefore, it is extremely important to conduct research on hypoxia susceptibility biomarkers. Moreover, it is important to develop a method for the evaluation of organisms’ basic hypoxia tolerance without the necessity of any oxygen deficiency exposure. This can contribute to new personalized medicine approaches’ development for diagnostics and the treatment of inflammatory and tumor diseases, taking into account hypoxia tolerance differences.

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“…It is known, that hypoxia plays a key role in both the system and local inflammatory reactions, mainly due to microcirculatory disorders and disseminated intravascular coagulation [3]. In this regard a number of studies have shown that severity of any inflammatory diseases, including inflammatory diseases of the gut such as Crohn's disease (CD) and ulcerative colitis (UC) depends on hypoxia resistance [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2020

Russ Open Med J

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Intestinal bowel diseases (IBD), including ulcerative colitis (UC), is the group of difficult to diagnose widespread among the population diseases. Pathogenesis of the disease is associated with a complex interaction of the genetic factors, the environment, the microbiome and the unpredicted reaction of the immune system, and the existing treatment methods are not effective enough. It is known, that hypoxia plays a key role in both system and local inflammatory reactions, mainly due to microcirculatory disorders and disseminated intravascular coagulation. Therefore a lot of studies have demonstrated that severity of any inflammatory diseases, including Crohn's disease (CD) and UC depends on hypoxia resistance. In this review we discussed microcirculation of blood and physiological hypoxia in the intestine, the role of hypoxia-inducible factors in the development of IBD and UC, as well as their influence on the severity of the inflammatory process. Authors described the protective effect of various PHD inhibitors and its benefits and disadvantages, so as new approaches of searching of very specific low molecular weight substanses as drugs for the control of IBD and UC.

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Age-Specific Features of Hypoxia Tolerance and Intensity of Lipopolysaccharide-Induced Systemic Inflammatory Response in Wistar Rats

Cited by 8 publications

References 14 publications

Physiological Responses at Rest and Exercise to High Altitude in Lowland Children and Adolescents

Physiological Responses at Rest and Exercise to High Altitude in Lowland Children and Adolescents

Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

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