Age-specific Fluoride Exposure in Drinking Water and Osteosarcoma (United States)

Abstract

Our exploratory analysis found an association between fluoride exposure in drinking water during childhood and the incidence of osteosarcoma among males but not consistently among females. Further research is required to confirm or refute this observation.

An Assessment of Bone Fluoride and Osteosarcoma

“…Similarly, case-control studies have not found any significant association between osteosarcoma risk and fluoridated drinking water (McGuire et al, 1991;Moss et al, 1995) or total lifetime fluoride (Gelberg et al, 1995). One exploratory analysis reported an increased risk among a subset of males exposed to fluoride in drinking water during childhood (Bassin et al, 2006).…”

Incorporation of the fluoride induced SiO bond cleavage and functionalized gold nanoparticle aggregation into one colorimetric probe for highly specific and sensitive detection of fluoride

“…However, a number of epidemiologic studies speculated the unintentionally http://dx.doi.org/10.1016/j.aca.2014.02.026 0003-2670/© 2014 Elsevier B.V. All rights reserved. chronic overexposure to F − account for many medical issues including fluorosis and osteosarcoma [2][3][4]. To avoid the adverse health problems caused by the uptake of F − from water, government authority, for example, the United States Environmental Protection Agency (USEPA) set a standard of 1 g mL −1 to protect against osteofluorosis and dental fluorosis, whereas 2 g mL −1 is considered as health-risk and 4 g mL −1 as the maximum contaminant level (MCL) [5].…”

Biomarkers for Bone Tumors: Discovery from Genomics and Proteomics Studies and Their Challenges

“…Gelsolin is involved in various biological functions such as apoptosis stimulator, cell motility, inflammation and wound healing (68). the incidence of osteosarcoma and fluo ride exposure in drinking water during childhood (57). However, their finding is only consistent among male subjects.…”