Age-specific Incidence and Prevalence of Keratoconus: A Nationwide Registration Study

Godefrooij, Daniël A.; Wit, G. Ardine de; Uiterwaal, Cuno S.P.M.; Imhof, Saskia M.; Wisse, Robert P. L.

doi:10.1016/j.ajo.2016.12.015

Cited by 399 publications

(353 citation statements)

References 9 publications

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“…In their study, a fourfold increased incidence was found in patients of Asian descent (0.23%) when compared with Caucasian patients (0.05%) 13. More recently, a large-scale evaluation from the Netherlands’ mandatory health insurance database showed prevalence approximately fivefold higher than previous reports, around 0.27%, or 1:375 patients 22. The prevalence estimate was derived from database review searching for KC diagnosis rather than corneal imaging analysis, and the mean KC diagnosis age was 28.3 years; thus, it is simultaneously uncertain that all patients identified actually had true KC and yet still likely that this rate represents an underestimation of disease as this strategy would not identify milder KC cases.…”

Section: Discussionmentioning

confidence: 75%

Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia

Torres-Netto¹,

et al. 2018

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Section: Discussionmentioning

confidence: 75%

Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia

Torres-Netto¹,

et al. 2018

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“…Although keratoconus (KCN) is not among the main diseases that may cause blindness in the world, it is important from a clinical and epidemiological aspect. In a recent nationwide registration study on more than 4 million patients from a mandatory insurance database in the Netherlands, the prevalence and incidence of KCN were estimated to be 5‐ to 10‐fold higher than previously reported. The prevalence, the number of given cases at a given time point, that is cited most often is 1:2000 , while the newly estimated was 1:375 .…”

Section: Noncancer Ocular Pathologiesmentioning

confidence: 69%

“…In a recent nationwide registration study on more than 4 million patients from a mandatory insurance database in the Netherlands, the prevalence and incidence of KCN were estimated to be 5‐ to 10‐fold higher than previously reported. The prevalence, the number of given cases at a given time point, that is cited most often is 1:2000 , while the newly estimated was 1:375 . The big difference between the 2 estimations may be accounted for by the advent of new imaging techniques, leading to more sensitive diagnosis .…”

Section: Noncancer Ocular Pathologiesmentioning

confidence: 69%

Ultraviolet radiation oxidative stress affects eye health

Ivanov

Mappes

Schaupp

et al. 2018

Journal of Biophotonics

152

132

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In the eye, ultraviolet radiation (UVR) is not known to contribute to visual perception but to mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure to UVR causes direct cellular damage, which has an important role in the development of cancer. This review provides an overview on the most recent knowledge on the role of UVR in oxidative stress (OS) in relation to noncancer ocular pathologies: various corneal pathologies, cataract, glaucoma and age-related macular degeneration. Possible OS signaling streams and mechanisms in the aging eye are discussed. Excessive exposure to UVR through live may seriously contribute to increase in OS of various eye tissues and thus lead to the advancement of serious ocular pathologies. Children are especially vulnerable to UVR because of their larger pupils and more transparent ocular media: up to 80% of a person's lifetime exposure to UVR is reached before the age of 18. Therefore, efficient everyday protection of the sensitive tissues of the eye by wearing of sunglasses, clear UVR-blocking spectacles or contact lenses should be considered from early age on. Many initiatives are taken worldwide to inform and raise the population's awareness about these possible UVR hazards to the eye.

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“…Diese Werte liegen 5- bis 10-fach höher als bisher angenommen [1]. Das Durchschnittsalter bei Erstdiagnose lag bei 28,3 Jahren und 60,6% der Patienten waren männlich [2]. …”

Section: Introductionunclassified

Therapie des Keratokonus

Händel¹,

Siebelmann²,

Matthaei³

et al. 2019

Kompass Ophthalmol

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Die vorliegende Arbeit gibt einen Überblick über die aktuellen therapeutischen Optionen des Keratokonus. Diese unterlagen in den letzten Jahren einem großen Wandel, einige neue therapeutische Möglichkeiten sind ergänzend hinzugekommen. Die Visusverbesserung durch Kontaktlinsen und Hornhauttransplantation wird mittlerweile durch die Anwendung von intracornealen Ringsegmenten ergänzt. Das Crosslinkingverfahren zum Stopp der Progression der Erkrankung wurde mittlerweile auch durch den Gemeinsamen Bundesausschuss im letzten Jahr positiv bewertet. Auch hier gibt es neue Trends, die das Verfahren in Zukunft beschleunigen und schmerzfrei machen könnten. Sehr neu sind die Therapiemöglichkeiten der mini-DMEK und der prädescemetalen Hornhautnähte beim akuten Keratokonus, für den bisher keine effektive operative Therapie zur Verfügung stand. Diese Übersicht gibt einen Einblick in die aktuellen Entwicklungen in Kombination mit modernster intraoperativer Bildgebung zur Therapie des Keratokonus.

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Age-specific Incidence and Prevalence of Keratoconus: A Nationwide Registration Study

Cited by 399 publications

References 9 publications

Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia

Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia

Ultraviolet radiation oxidative stress affects eye health

Therapie des Keratokonus

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