Age-specific seroprevalence of human polyomavirus 12 and Saint Louis and New Jersey polyomaviruses

Abstract

The presence of specific antibodies against human polyomavirus 12, Saint Louis polyomavirus and New Jersey polyomavirus was investigated by using virus-like particle-based ELISAs with serum samples from 706 Italians aged 1- to 100-years-old. The findings indicate that these polyomaviruses circulate widely in humans, with peak seroprevalence, observed at adulthood, of 97.3%, 93.3%, 57.5%, for human polyomavirus 12, Saint Louis polyomavirus and New Jersey polyomavirus, respectively.

Seroprevalence of fourteen human polyomaviruses determined in blood donors

“…In contrast to our data, a very recent study reported 90% seroprevalence for HPyV12, in an Italian adult population [ 37 ]. This percentage is considerably higher than our finding and the 20% seroprevalence obtained previously for HPyV12 by Ehlers and co-workers using recombinant VP1 and VP1-based VLP ELISA [ 35 , 38 ].…”

“…Suboptimal HPyV12 antigen recognition, resulting from the use of a premature translation initiation site in HPyV12 VP1, causing a 16 amino acids longer version of VP1 [ 39 ], was experimentally ruled out ( S1 Fig ). Also for NJPyV a much higher seroprevalence was found in the Italian population (50%) than in our population (5%) [ 37 ]. Overall, more (sero)epidemiological studies are needed to solve these discrepancies and to define the natural host(s) of these viruses, for example by studying seroprevalence in different geographic regions while using comparable serological methods.…”

Seroprevalence of fourteen human polyomaviruses determined in blood donors

“…In contrast to our data, a very recent study reported 90% seroprevalence for HPyV12, in an Italian adult population [36]. This percentage is considerably higher than our finding and the 20% seroprevalence obtained previously for HPyV12 by Ehlers and co-workers using recombinant VP1 and VP1-based VLP ELISA [34,37].…”

“…Suboptimal HPyV12 antigen recognition, resulting from the use of a premature translation initiation site in HPyV12 VP1, causing a 16 amino acids longer version of VP1 [38], was experimentally ruled out (S1 Fig). Also for NJPyV a much higher seroprevalence was found in the Italian population (50%) than in our population (5%) [36]. Overall, more (sero)epidemiological studies are needed to solve these discrepancies and to define the natural host(s) of these viruses, for example by studying seroprevalence in different geographic regions while using comparable serological methods.…”

Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China

“…For instance, viral loads of human PyVs including MCPyV do not significantly differ between HIV-positive and -negative men 9 . Regarding New Jersey polyomavirus (NJPyV), which was discovered in 2014 in vascular endothelial cells of a pancreatic transplant recipient, only a few serological surveys on this virus have been reported in healthy populations and no study on HIV-positive individuals has been described to date 4,10,11 .…”