Age specificity of the relationship between serum cholesterol and mood in obese women

SummaryThe role of emotional functioning in the development and maintenance of obesity has been investigated, but the literature is poorly integrated. A systematic review and meta-analysis was performed to explore emotional processing impairments in obesity. PubMed, Web of Knowledge and PsycINFO databases were searched in March 2016, yielding 31 studies comparing emotional processing competencies in individuals with obesity, with or without binge eating disorder (BED), and control groups. Meta-analyses demonstrated that individuals with obesity had higher scores of alexithymia (d = 0.53), difficulty in identifying feelings (d = 0.34) and externally oriented thinking style (d = 0.31), when compared with control groups. On other competencies, patients with obesity, especially those with comorbid BED, reported lower levels of emotional awareness and difficulty in using emotion regulation strategies, namely, reduced cognitive reappraisal and acceptance, and greater suppression of expression. No evidence of impaired ability to recognize emotions in others or verbally express emotions was found. A general emotion-processing deficit in obesity was not supported. Instead, an emotional avoidance style may occur modulating later responses of emotion regulation. Additional research is needed to extend the comprehension of these conclusions and the role of BED in emotional functioning in obesity.

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“…Similarly, in a correlational study, Troisi et al . reported no significant association between BMI and TAS total score.…”

Section: Resultsmentioning

confidence: 95%

Emotional processing in obesity: a systematic review and exploratory meta‐analysis

et al. 2017

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“…In 73 obese women aged 16-76 years, Troisi et al (2001) found no significant association between serum cholesterol levels and depression, anger and alexithymia (a cognitive-affective disturbance characterized by difficulty in identifying and describing one's own feelings) in the younger age group (<50 years). In contrast, in the subgroup of older women, TC levels were negatively and significantly correlated with mood ratings.…”

Section: Negative Moodmentioning

confidence: 88%

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

Troisi

2009

Neuroscience & Biobehavioral Reviews

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“…Obesity is a world-wide health problem that is highly correlated with morbidity and mortality from cardiovascular disease [1], diabetes [2], osteoarthritis [3] and depression [4]. The prevalence of obesity is increasing in adults [5], as well as children [6], with less physical activity, more sedentary occupations and a greater use of automation to complete simple tasks considered as possible contributing factors [5].…”

Section: Introductionmentioning

confidence: 99%

Development of a dosing strategy for enoxaparin in obese patients

Green

Duffull

2003

Brit J Clinical Pharma

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Aims Enoxaparin dosing is currently based on total body weight. It is not known how to dose adjust for patients who are overweight or obese. This population pharmacokinetic pharmacodynamic (PKPD) study was undertaken to determine a suitable dosing strategy for such patients. Methods Patients admitted to the Royal Brisbane Hospital and prescribed enoxaparin as part of their normal care were eligible for inclusion into the study. Approximately three blood samples were taken per patient to determine anti-Xa concentrations. The occurrence of bruising was also recorded. A population pharmacokinetic-pharmacodynamic analysis using NONMEM was undertaken. Simulations were performed using MATLAB. Results Ninety-six patients were recruited in a prospective study. One-third of patients had a body mass index < 24.9 kg m -2 , one-third from 25 to 29.9 kg m -2 , and one-third > 30 kg m -2 . A two-compartment linear model with additive error was fitted to the data. A covariate analysis showed clearance was best described by lean body weight and the central volume compartment by total body weight. The probability of bruising using a logistic regression model was best described by C max and age. Simulations suggest that patients over 50 years of age whose total body weight is > 90 kg, or under 50 years of age whose total body weight is > 120 kg are likely to have a smoother concentration-time profile and less bruising if a dose of 100 IU kg -1 (1 mg kg -1 ) based on lean body weight is administered every 8 h. Conclusions Dose adjustments of enoxaparin in obese patients are likely to reduce the prevalence of bruising, although prospective validation of this is required.

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Age specificity of the relationship between serum cholesterol and mood in obese women

Cited by 20 publications

References 26 publications

Emotional processing in obesity: a systematic review and exploratory meta‐analysis

Emotional processing in obesity: a systematic review and exploratory meta‐analysis

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

Development of a dosing strategy for enoxaparin in obese patients

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