Age-standardized incidence, prevalence, and mortality rates of autoimmune diseases in women of childbearing age from 1990 to 2019

Cao, Fan; He, Yi-Sheng; Sang, Ni; Liu, Yu-Chen; Hu, Xiao; Ni, Qin-Yu; Tao, Li-Ming; Hou, Sheng-Ping; Jiang, Zheng-Xuan; Pan, Hai-Feng

doi:10.1016/j.autrev.2023.103450

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…This condition preferentially afflicts the geriatric female demographic, accounting for approximately 1% of the global population. Manifesting primarily through inflammation in small and medium-sized joints, RA substantially erodes the quality of patients' life 4 , 5 . Further to this, sustained inflammation poses risks to additional organs, including the cardiovascular system and kidneys.…”

Section: Introductionmentioning

confidence: 99%

Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12

Zhang,

Zhao

et al. 2024

Int. J. Biol. Sci.

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and the production of autoantibodies. Previous studies have indicated an association between high-salt diets (HSD) and an increased risk of RA, yet the underlying mechanisms remain unclear. Macrophage pyroptosis, a pro-inflammatory form of cell death, plays a pivotal role in RA. In this study, we demonstrate that HSD exacerbates the severity of arthritis in collagen-induced arthritis (CIA) mice, correlating with macrophage infiltration and inflammatory lesions. Given the significant alterations observed in macrophages from CIA mice subjected to HSD, we specifically investigate the impact of HSD on macrophage responses in the inflammatory milieu of RA. In our in vitro experiments, pretreatment with NaCl enhances LPS-induced pyroptosis in RAW.264.7 and THP-1 cells through the p38 MAPK/NF-κB signaling pathway. Subsequent experiments reveal that Slc6a12 inhibitors and SGK1 silencing inhibit sodium-induced activation of macrophage pyroptosis and the p38 MAPK/NF-κB signaling pathway, whereas overexpression of the SGK1 gene counteracts the effect of sodium on macrophages. In conclusion, our findings verified that high salt intake promotes the progression of RA and provided a detailed elucidation of the activation of macrophage pyroptosis induced by sodium transportation through the Slc6a12 channel.

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Section: Introductionmentioning

confidence: 99%