Abstract:SUMMARY
BackgroundUrgent endoscopy is indicated for suspected upper gastrointestinal malignancy. However, there is limited evidence on the age threshold for performing urgent endoscopy in uncomplicated dyspepsia (that is, without alarm features).
“…There is no evidence that GC is characterised by uncomplicated dyspepsia 18. Two audits from the UK suggest that the large majority of patients (>92%) with upper gastrointestinal malignancy who present with uncomplicated dyspepsia have inoperable disease 19 20. Consequently uncomplicated dyspepsia is not so much an ‘early sign’ of GC, but a symptom in a minority of patients with GC.…”
False-negative rates of 0% (within 12 months) and 8% (within 3 years) for diagnosis of GC are reassuring, but an inadequate number of biopsies compromises the quality assurance of endoscopy. GC presents without alarm symptoms in <10%.
“…There is no evidence that GC is characterised by uncomplicated dyspepsia 18. Two audits from the UK suggest that the large majority of patients (>92%) with upper gastrointestinal malignancy who present with uncomplicated dyspepsia have inoperable disease 19 20. Consequently uncomplicated dyspepsia is not so much an ‘early sign’ of GC, but a symptom in a minority of patients with GC.…”
False-negative rates of 0% (within 12 months) and 8% (within 3 years) for diagnosis of GC are reassuring, but an inadequate number of biopsies compromises the quality assurance of endoscopy. GC presents without alarm symptoms in <10%.
This simple clinical-cum-laboratory test-based model performed very well in identifying dyspeptic patients at risk of UGIM. This can serve as a useful decision-making tool for referral for endoscopy.
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