Age thresholds for changes in semen parameters in men

Stone, Bronte A.; Alex, Allyse; Werlin, L.B.; Marrs, Richard P.

doi:10.1016/j.fertnstert.2013.05.046

Cited by 177 publications

(153 citation statements)

References 35 publications

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“…After the age of 45, semen volume gradually decreases due to functional decline of accessory glands. In addition, sperm morphology is also affected with aging and the percentage of sperms with normal morphology begins to decrease after the age of 40 [22]. Recently, a meta-analysis was conducted to evaluate the effects of aging on semen parameters including semen volume, sperm concentration, total sperm count, morphology, total motility, progressive motility, and DNA fragmentation.…”

Section: The Impact Of Aging On Semen Parametersmentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

195

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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Section: The Impact Of Aging On Semen Parametersmentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

195

118

View full text Add to dashboard Cite

show abstract

“…Possible fluctuations in seminal quality are associated with factors such as breed (Rijsselaere et al, 2007), age (Stone et al, 2013), seasonality (Chemineau et al, 2008;Zhang et al, 2013), temperature (Thonneau et al, 1998), photoperiod (Mazzarri et al, 1970;Kozdrowski and Dubiel, 2004), and other factors of different etiology. All of these factors require careful control to attain the best semen quality for artificial insemination.…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation in sperm characteristics of boars in southern Uruguay

2015

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-The objective of this study was to evaluate the effects of season, natural photoperiod, and room temperature at the housing facility on boar semen characteristics in Uruguay (34º66'S; 56º29'W). For this purpose, 117 ejaculates, obtained from eight adult males collected through 12 consecutive months, were assessed for sperm viability, DNA integrity, abnormalities (total, primary, and secondary), ejaculate volume, and sperm concentration. Viability, total and primary abnormalities, volume, and sperm concentration were affected by season. Sperm viability, volume, and sperm concentration were affected by natural photoperiod. In general, autumn and the decreasing photoperiod had a negative impact on most of the semen characteristics, except for volume. Housing temperature did not affect semen characteristics. In boars living in temperate climates, semen quality is negatively affected during autumn and is related to photoperiod changes; however, the effects of temperature changes in housingdo not affect these seminal characteristics. In this scenario, seasonal differences in semen quality may have a negative effect on sow fertilization. Consequently, semen quality control especially during autumn is imperative for the best boar selection to be used for insemination purposes. Seasonal differences in semen quality may have a negative effect on sow reproductive performance. This issue will be addressed in a future investigation.

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“…Nonetheless, a threshold for this parameter has not yet been established as others claim a more gradual decline in sperm concentrations throughout life, with no definite verging point [17]. A more recent study conducted by Stone and peers revealed that, males above 40 years old displayed a consistent significant decline in sperm concentration [46]. Interestingly, authors have found a negative correlation between sperm concentration and ROS levels in the semen.…”

Section: Sperm Parameters Decline With Agingmentioning

confidence: 99%

“…Several studies have evaluated the variations in sperm concentration that occur with aging [44][45][46]. Authors have found a tendency for a continuous sperm concentration decline with aging, especially aggravated after the age of 45 years [45].…”

Section: Sperm Parameters Decline With Agingmentioning

confidence: 99%

“…As spermatozoa gain motility during mitochondria activation at their passage through the epididymis, it is highly affected by any age related alteration to this process [54]. Several studies have reported a significant decline in sperm motility associated with male aging [17,40,46]. In fact this decrease can reach 0.7% per year, and may be directly related to male factor infertility of advanced-age patients [40,47].…”

Section: Sperm Parameters Decline With Agingmentioning

confidence: 99%

See 1 more Smart Citation

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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The rise in life expectancy and the desire to establish a stable career prior to parenthood leads couples to a delayed childbearing. Advanced parental age at the time of pregnancy portrays several risks, with the majority of couples above 35 experiencing reproductive impairments. While the effect of women's age on fertility is well known, the influence of paternal age is less understood. Thus, efforts have been made to comprehend the influence of APA on pregnancy upkeep and disease risk for the offspring. Over the last decades numerous studies aimed to establish the relationship between APA and male fertility potential. It has been found that APA is related to testicular and hormonal alterations, along with a decreased sperm production, quality and DNA integrity. As expected, these alterations compromise the reproductive potential of older men and have been associated with several fecundity problems, including increased time to pregnancy and abortion rates, and decreased fertilization and pregnancy rates. Additionally, alterations in offspring health, like genetic disorders, mental illnesses, congenital anomalies and cancer, have also been linked to APA. As a result, APA influence on the reproductive outcome must be taken into consideration when counseling couples attending family planning consultations or pursuing fertility treatments. Nonetheless, to date, there are still no definite results regarding this problem and an age threshold has yet not been established and additional research to better elucidate the effects of APA on fertility and offspring's health is needed. Likewise, establishing an age threshold for APA would be of great value to males thinking of delaying parenthood, and to physicians for medical advice purposes.

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Age thresholds for changes in semen parameters in men

Cited by 177 publications

References 35 publications

Effects of aging on the male reproductive system

Effects of aging on the male reproductive system

Seasonal variation in sperm characteristics of boars in southern Uruguay

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

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