2022
DOI: 10.3389/fnagi.2021.815361
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Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model

Abstract: Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Although the cause of AD neurodegenerative changes is not fully understood, extensive evidence suggests that the misfolding, aggregation and cerebral accumulation of amyloid beta (Aβ) and tau proteins are hallmark events. Recent reports have shown that protein misfolding and aggregation can be induced by administration of small quantities of preformed aggregates, following a similar principle by which prion diseases can be transmit… Show more

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Cited by 8 publications
(3 citation statements)
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“…Similar to old human brains, old cattle brains promote amyloidosis and display Alzheimer's disease-like pathology [48]. -synuclein contributes to the formation of amyloid deposits [17,18].…”
Section: Discussionmentioning
confidence: 99%
“…Similar to old human brains, old cattle brains promote amyloidosis and display Alzheimer's disease-like pathology [48]. -synuclein contributes to the formation of amyloid deposits [17,18].…”
Section: Discussionmentioning
confidence: 99%
“…These proteins can self-replicate and contribute to disease progression by inducing misfolding in their normal counterparts, leading to abnormal accumulation and subsequent brain damage. Further research is necessary to fully comprehend the intricacies of these mechanisms and their implications for AD pathogenesis [ 24 , 25 , 26 , 27 ].…”
Section: Etiopathophysiology Of Admentioning
confidence: 99%
“…In this framework, some of the major traits of cognitive decline might be related to the pathological extracellular Aβ deposition and intracellular tau aggregation, together with an impaired intracellular degradative pathway (autophagy), which are regarded as hallmarks for the early onset of Alzheimer’s disease in humans and animals ( Reddy et al, 2018 ; Rao et al, 2022 ). Accordingly, the occurrence of AD-like pathology was reported in some aged cow, since they showed scattered Aβ deposits and substantial amount of amyloid accumulation in cortex and hippocampus ( Moreno-Gonzalez et al, 2021 ). Thus, considering the crucial role for the hippocampus upon molecular and behavioral symptoms during aging, a deeper characterization of the age-dependent brain physiology paves the way for the development of strategies aimed at counteracting, or slowing down, the detrimental effects of the hippocampal decline in humans and farm animals as well.…”
Section: Introductionmentioning
confidence: 99%