Aged rats are more prone to “ecstasy” neurotoxicity than adolescent rats

Azevedo, Rita; Costa, Vera Marisa; Barbosa, Daniel José; Gomes, A.; Pita, Inês; Sequeira, Ana; Pereira, Frederico C.; Duarte‐Araújo, Margarida; Duarte, José Alberto; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Félix; Capela, João Paulo

doi:10.1016/j.toxlet.2014.06.804

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the use of non-rodents as a second species in toxicity testing to support human safety is important (Lees et al, 2014). Aged rats are more prone to ecstasy neurotoxicity than adolescent rats suggesting that age is an important determinant for the neurotoxic events promoted by ecstasy (Azevedo et al, 2014).…”

Section: Repeated Dose Toxicity Studymentioning

confidence: 99%

Toxicity studies of drugs and chemicals in animals: an overview

Saganuwan¹

2017

BJVM

View full text Add to dashboard Cite

SummarySaganuwan, S. A., 2017. Toxicity studies of drugs and chemicals in animals: An overview. Bulg. J. Vet. Med., 20, No 4, Toxicity study is the investigation of either short or long-term toxic effects of a drug or chemical on animals. The toxicity is dose-dependent as asserted by Paracelsus over 500 years ago. However, short-term toxic effect is determined using median lethal dose (LD 50 ) first introduced by Trevan in 1927 and revised many times. Presently there is a growing preponderance of rejection of scientific papers on acute toxicity study, simply because of the belief that in the current hazard and safety assessment of drugs and chemicals, LD 50 values are no longer used. In view of this, literature search was carried out with a view to investigating the relevance of LD 50 in development and assessment of drugs and chemicals. The findings revealed that in the past, many animals had been used for LD 50 determination. OECD has reduced the number of test animals to 5-15 and presently it is further reduced to 2-6. Acute toxicity study is being carried out in medicinal plants research and in the study of patent medicine. Although the application of LD 50 has been drastically reduced, it is still applied and accepted in some parts of the world. Moreover, animals on which LD 50 tests are conducted, should be allowed to die to see the end effect of the test drug or chemical because euthanisia of test animals may mask some toxicity signs of the test agents. Therefore, toxicity study of drugs and chemicals is a scientific process necessary for discovery and development of drugs as well as identification of potential toxicants.

show abstract

Section: Repeated Dose Toxicity Studymentioning

confidence: 99%

Toxicity studies of drugs and chemicals in animals: an overview

Saganuwan¹

2017

BJVM

View full text Add to dashboard Cite

show abstract

Aged rats are more prone to “ecstasy” neurotoxicity than adolescent rats

Cited by 1 publication

References 0 publications

Toxicity studies of drugs and chemicals in animals: an overview

Toxicity studies of drugs and chemicals in animals: an overview

Contact Info

Product

Resources

About