Ageing and Detoxication

Stern, Karl; Hinds, Ewart G.; Askonas, Brigitte A.

doi:10.1176/ajp.102.3.325

Cited by 12 publications

(2 citation statements)

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“…Glycine conjugation also appears to be impaired in old age. Thus, Stern et al (1945) showed that elderly subjects converted only 50% o f an oral dose o f benzoic acid to hippuric acid. The impairment appeared to be due to a relative lack of glycine since administration of the amino acid increased the amount of hippuric acid formed (Stern et al, 1946).…”

Section: Discussionmentioning

confidence: 99%

Drug Metabolism in a Case of Progeria

Caldwell¹,

Smith²,

Davies³

1978

Gerontology

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A case of premature ageing (progeria) in a 3-year-old Indian child is described. The conjugations of paracetamol with glucuronic acid and sulphate, of benzoic acid with glycine and of phenylacetic acid with glutamine have been investigated in this child, in view of suggestions that these reactions are impaired in old age. The results suggest that the glucuronic acid conjugation pathway may be quantitatively less important in the progeric child than in normal children and adults.

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Section: Discussionmentioning

confidence: 99%

Drug Metabolism in a Case of Progeria

Caldwell¹,

Smith²,

Davies³

1978

Gerontology

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“…She settled in Montreal, became a Canadian citizen and obtained a first class degree in biochemistry from McGill University in 1944. After graduating, she spent two years at the Allen Memorial Institute of Psychiatry, publishing in this field [1], before moving to Cambridge to study in the laboratory of Malcolm Dixon. Her PhD thesis was on muscle enzymes, particularly creatine phosphokinases.…”

Section: Photo Courtesy Of Marc Feldmanmentioning

confidence: 99%

Dr Brigitte Askonas (1923‐2012)

2013

Eur J Immunol

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Amino Acid Conjugation: A Novel Route of Xenobiotic Carboxylic Acid Metabolism in Man

Knights

Miners

2012

Encyclopedia of Drug Metabolism and Interactions

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Amino acid conjugation is a novel biotransformation pathway in man for a limited number of xenobiotic carboxylic acids. It involves two mitochondrial enzymatic processes: formation of a reactive xenobiotic‐CoA thioester intermediate, catalyzed by an ATP‐dependent acid:CoA synthetase (ACSM), and linkage of the activated acyl group via an acyl‐CoA:amino acid N ‐acyltransferase (GLYAT) to the amino group of the acceptor amino acid. However, knowledge of amino acid conjugation in terms of enzyme multiplicity, protein structure, and xenobiotic substrate selectivity is not well advanced.

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Ageing and Detoxication

Cited by 12 publications

References 1 publication

Drug Metabolism in a Case of Progeria

Drug Metabolism in a Case of Progeria

Dr Brigitte Askonas (1923‐2012)

Amino Acid Conjugation: A Novel Route of Xenobiotic Carboxylic Acid Metabolism in Man

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