Ageing and infection

Gavazzi, G.; Krause, Karl‐Heinz

doi:10.1016/s1473-3099(02)00437-1

Cited by 872 publications

(622 citation statements)

References 106 publications

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“…However, the definition of complication severities after LAG in the elderly was not strictly defined in these previous reports. Severe postoperative complications can easily become fatal in elderly patients as the result of age-related decline in immune functions, which could increase the prevalence and severity of infectious diseases in elderly patients [29][30][31][32]. Therefore, we analyzed postoperative complications depending on their severity and studied risk factors for severe complications in elderly LADG cases.…”

Section: Discussionmentioning

confidence: 99%

Potentially fatal complications for elderly patients after laparoscopy-assisted distal gastrectomy

et al. 2013

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Background The safety of surgery for gastric cancer in the elderly has been shown previously. However, potentially fatal complications based on an established severity grading system were not well described, and associated risk factors have not been assessed. The present study sought to examine severity-dependent postoperative complications after laparoscopy-assisted distal gastrectomy (LADG) in elderly patients and risk factors of potentially fatal postoperative complications. Methods The study included 189 patients aged 70 years or older and who underwent LADG for early gastric cancer. Patient characteristics, perioperative outcomes, postoperative complications including severity assessment using the Clavien-Dindo classification, and risk factors related to postoperative complications were analyzed. Results The overall complication rate was 24.9 % (47/189). The most frequent complication was abdominal fluid collection (9 cases, 4.8 %). Severe complications classified as grade III or above in the Clavien-Dindo grading system were found in 20 (10.6 %) patients. Multivariate analysis identified preoperative serum albumin concentration (odds ratio, 5.200; 95 % CI, 1.706-15.850), Roux-en-Y reconstruction (odds ratio, 3.611; 95 % CI, 1.103-11.817), and simultaneous cholecystectomy (odds ratio, 5.008; 95 % CI, 1.378-18.201) as independent predictors of a higher rate of severe postoperative complications after LADG in elderly patients. Conclusion The incidence of severe complications after LADG in the elderly was quite acceptable considering the risks associated with radical surgery with extensive lymphadenectomy. Preoperative serum concentrations of albumin (\4.0 g/dl), Roux-en-Y reconstruction, and simultaneous cholecystectomy are independent risk factors for severe postoperative complications in these patients.

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Section: Discussionmentioning

confidence: 99%

Potentially fatal complications for elderly patients after laparoscopy-assisted distal gastrectomy

et al. 2013

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“…It is therefore assured a prompt and effective response to the recall antigens, while there is a restrict response to new challenges. 24,25 Naive cells are essential in the defence against acute infections and as so their decrease in elderly asthma, particularly in CD8 phenotypes, should be regarded as a bad prognosis factor.…”

Section: Discussionmentioning

confidence: 99%

Aging and asthma – changes in CD45RA, CD29 and CD95 T cells subsets

Todo-Bom

Mota-Pinto

Alves

et al. 2012

Allergologia et Immunopathologia

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“…1 Infections in general are more frequent in older people compared to younger adults and are associated with hospitalization and mortality. [2][3][4] Multiple explanations for the increased rate of infections among older patients have been suggested, including co-morbid illnesses, exposure to instrumentation and procedures, institutionalization, immunosenescence, malnutrition, and poor performance status. 5 Elderly patients in institutions are at higher risk for infections because of more pronounced impairment of defenses against infection and large number of comorbidities, in addition to higher risk for rapid dissemination of viral infections and multidrug resistant organisms.…”

Section: Infections In Older Patientsmentioning

confidence: 99%