Ageing is associated with changes in glutamate release, protein tyrosine kinase and   protein kinase II in rat hippocampus

Mullany, Patricia M.; Connolly, Siobhan; Lynch, Marina A.

doi:10.1016/0014-2999(96)00464-5

Cited by 34 publications

(13 citation statements)

References 17 publications

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“…This suggests that tyrosine phosphorylation of one or more proteins is required to permit a depolarizing pulse of KCl to stimulate calcium entry and to release glutamate. The inhibitory effect of genistein on endogenous glutamate release is consistent with earlier findings (Mullany et al, 1996;Phillis et al, 1996).…”

Section: Casey Et Alsupporting

confidence: 91%

Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein

et al. 2002

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A great deal of recent evidence points to a role for tyrosine kinase in expression of LTP. Data have been presented that are consistent with the idea that tyrosine phosphorylation of proteins occurs in both the presynaptic and postsynaptic areas. In this study, we set out to investigate the role that tyrosine kinase might play presynaptically to modulate release of glutamate in an effort to understand the mechanism underlying the persistent increase in release that accompanies LTP in perforant path-granule cell synapses. We report that LTP was associated with increased calcium influx and glutamate release. LTP was also associated with an increase in phosphorylation of the alpha-subunit of calcium channels and ERK in synaptosomes prepared from dentate gyrus, and these effects were inhibited when LTP was blocked by the tyrosine kinase inhibitor, genistein. LTP was accompanied by increased protein synthesis and increased phosphorylation of CREB in entorhinal cortex, effects that were also blocked by genistein. We conclude that tetanic stimulation leads to enhanced tyrosine phosphorylation of certain presynaptically located proteins that modulate glutamate release and contribute to expression of LTP.

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Section: Casey Et Alsupporting

confidence: 91%

Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein

et al. 2002

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“…This observation supports the data that indicate an inhibitory effect of tyrphostin AG879 on release in vitro. It is also consistent with the proposal that tyrosine kinase modulates glutamate release, which was suggested by the previous observation that activity of tyrosine kinase was increased when release was increased and decreased when release is decreased (Mullany et al, 1996). The correlation between LTP and increased glutamate release described here supports the findings of several studies that have coupled increased glutamate release with maintenance of LTP in dentate gyrus (Bliss and Collingridge, 1993;Canevari et al, 1994;McGahon and Lynch, 1996;McGahon et al, 1998).…”

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confidence: 91%

Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus

Maguire¹,

Casey²,

Kelly³

et al. 1999

Hippocampus

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“…Whether the decreases in synaptic strength and postsynaptic responsiveness to glutamate receptor activation observed in aged animals (Barnes et al, 1992) represent a condition of enhanced phosphatase activity remains to be determined. Furthermore, while an age-related change in kinase activity cannot be ruled out (Battaini et al, 1990;Magnoni et al, 1991;Mullany et al, 1996), the fact that similar levels of LTP are observed when weak synaptic activity is paired with postsynaptic depolarization suggests that age-related differences in hippocampal synaptic plasticity are not due to changes in kinase expression/activity (Barnes et al, 1996).…”

Section: Foster and Norrismentioning

confidence: 90%

Age-associated changes in Ca2+-dependent processes: Relation to hippocampal synaptic plasticity

1997

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Ageing is associated with changes in glutamate release, protein tyrosine kinase and protein kinase II in rat hippocampus

Cited by 34 publications

References 17 publications

Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein

Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein

Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus

Age-associated changes in Ca2+-dependent processes: Relation to hippocampal synaptic plasticity

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