Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: An individual participant meta-analysis

Abstract

Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: an individual participant meta-analysis, Nitric Oxide (2015), http://dx.doi.org/doi:10.1016/j.niox.2015.04.007. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Results The pooled effect of beetroot juice on all BP outcomes was not significant. Beetroot 54 juice ingestion determined a significant decrease in nocturnal systolic BP variability in

The Nitrate-Nitrite-NO Pathway and Its Implications for Heart Failure and Preserved Ejection Fraction

“…There was no significant change in resting blood pressure with NO 3 − supplementation. This is in contrast to blood pressure-lowering effect in healthy volunteers and drug-naive hypertensive subjects 89, 150 and may partially be explained by recent data indicating that the BP-lowering effect of inorganic nitrate is modified by age 130 or the renal effects in pathways downstream of the AT1-receptor. 151 We also assessed local skeletal muscle mitochondrial oxidative capacity following a standardized forearm exercise protocol and demonstrated a trend towards improved skeletal muscle mitochondrial function following NR-BRJ.…”

“…100, 108 The hypotensive effects of nitrate are dose-dependent and fairly mild, averaging −4.4/−1.1 mm Hg in a recent meta-analysis, 65 though age may modify the blood pressure response. 130 …”

“…This suggests that resting hypotension is an unlikely adverse effect of inorganic nitrate in this population. 130 Importantly, the lack of a blood pressure response to nitrate has also been shown in both elderly 130, 131 and diabetic individuals, 126 further suggesting that there may be important differences in nitrate effects in different patient populations.…”

Effects of Dietary Nitrate Supplementation on Physiological Responses, Cognitive Function, and Exercise Performance at Moderate and Very-High Simulated Altitude

“…Elevated NO bioavailability following ${\text{NO}}_3^{-}$ supplementation might be expected to lower BP, due to NO-dependent relaxation of smooth muscle and subsequent vasodilation (Larsen et al, 2006; Webb et al, 2008; Vanhatalo et al, 2010; Siervo et al, 2013, 2015). However, in the present study there was no apparent difference in resting MAP assessed prior to simulated altitude exposure between BRJ and PLA.…”

Potential Benefits of Caffeine Alone or in Combination with Nitrate Supplementation in Blood Pressure Control in the Elderly

“…Interestingly, caffeine with NO availability works as a protective combination during ethanol induced cerebral artery constriction. 46 Analyzing these two substances from the literature results we can assume that acute inorganic nitrate or inorganic nitrate rich meals consumption can decrease BP enough to modulate caffeine's impact on the elderly BP Siervo M et al 51 (Table 3) shows that inorganic nitrate vascular effects are contrary to those promoted by caffeine consumption. In young subjects, inorganic nitrate consumption has been show to improve mitochondrial efficiency 48 which is related to its cryogenic potential.…”