Ageing, tumour necrosis factor-alpha (TNF-<i>α</i>) and atherosclerosis

Bruunsgaard, Helle; Skinhøj, Peter; Pedersen, Asger Ken; Schroll, Marianne; Pedersen, Bente Klarlund

doi:10.1046/j.1365-2249.2000.01281.x

Cited by 353 publications

(226 citation statements)

References 48 publications

(59 reference statements)

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…As expected, advanced age and menopausal status were associated with elevated CRP levels. 39,40 Iannuzzi et al found that higher hs-CRP levels were associated with obstructive sleep apnea, and the effects were mediated by being overweight and obese. 41 Similarly, decreasing body mass index by lifestyle interventions such as exercise and dietary restrictions was shown to decrease hs-CRP levels in a randomized study of 439 postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study

Chiang¹

2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Background: Elevated plasma levels of high-sensitivity C-reactive protein (hs-CRP) have been associated with increased adverse health outcomes. The aim of this study was to investigate the association of sleep duration with risk of elevated hs-CRP levels in Taiwanese adults. Methods: We examined the association between sleep duration and hs-CRP in 353 healthy adults recruited from the physical examination center at a regional hospital in southern Taiwan. Elevated hs-CRP was defi ned as a plasma level ≥ 0.20 mg/dL. Short sleep duration was defi ned as ≤ 5.5 h per day. Multiple logistic regression analysis was used to assess the association of short duration of sleep with elevated hs-CRP levels. Results: In this study, short duration of sleep (odds ratio [OR] = 2.20; 95% confi dence interval [CI]: 1.11-4.30), aged 70 years or older (OR = 4.58; 95% CI: 1.70-12.66), menopause (OR = 2.81; 95% CI: 1.52-5.3), higher heart rate (OR = 1.38; 95% CI: 1.10-1.75), higher body mass index (OR = 1.20; 95% CI: 1.09-1.34), higher white blood cell count (OR = 1.38; 95% CI: 1.14-1.66), and higher uric acid level (OR = 1.31; 95% CI: 1.06-1.63) were signifi cantly associated with an increased risk of elevated hs-CRP levels. Conclusions: In this study of healthy Taiwanese adults, short duration of sleep was signifi cantly associated with elevated hs-CRP levels. Activation of pro-infl ammatory pathways might represent a mechanism by which short sleep duration affects health. Keywords: sleep duration, C-reactive protein, high-sensitivity CRP, hs-CRP Citation: Chiang JK. Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study. J Clin Sleep Med 2014;10(7):743-749.http://dx.doi.org/10.5664/jcsm.3862 S C I E N T I F I C I N V E S T I G A T I O N SC -reactive protein is secreted by the liver in response to acute infl ammation and infection.1 The high-sensitivity C-reactive protein (hs-CRP) assay has low detection limits, and good performance for apparently healthy subjects.2 Elevated hs-CRP levels have been associated with infl ammation, aging, cancer, adverse outcomes of angina pectoris, coronary artery disease, adverse outcomes of chronic obstructive pulmonary disease, stroke, and increased risk of mortality. [3][4][5][6][7][8][9][10] In addition, elevated hs-CRP has been shown to be a stronger predictor of cardiovascular disease than low-density lipoprotein cholesterol.11 A recent study of more than 4,000 subjects followed for six years revealed that elevated hs-CRP was associated with type 2 diabetes. 12Another study with a follow-up of 11 years also demonstrated the same association of hs-CRP with diabetes.13 As expected, patients with lower glycosylated hemoglobin (A1C) levels were found to have signifi cantly lower hs-CRP levels.14 In recent years it has been shown that sleep duration might affect health in a number of ways, such as its associations with insulin resistance, diabetes, hyperleptinemia, heart disease, and mortality.15-17 Specifi cally, sho...

show abstract

Section: Discussionmentioning

confidence: 99%

Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study

Chiang¹

2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

show abstract

“…Elevated plasma levels of TNF-α were associated with the pathogenesis of diabetes and atherosclerosis (21). TNF-α was related to endothelial dysfunction in patients with type 2 diabetes mellitus after myocardial infarction (6) and actively involved in the progression of atherosclerosis (22).…”

Section: Discussionmentioning

confidence: 99%

Rosiglitazone Attenuates Endothelial Progenitor Cell Apoptosis Induced by TNF-α via ERK/MAPK and NF-κB Signal Pathways

Zhao

et al. 2011

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. The discovery of endothelial progenitor cells (EPCs) provides us with a novel treatment strategy for complications requiring therapeutic revascularization and vascular repair. However, the feasibility of this strategy may be limited due to reduced number and impaired function of EPCs under stimulation of TNF-α. The present study was designed to investigate the effect of rosiglitazone on EPC apoptosis induced by TNF-α and the molecular mechanisms involved. Rosiglitazone attenuated apoptosis of TNF-α-stimulated EPCs in a dose-dependent manner. Rosiglitazone decreased caspase-3 activity and cleavages of caspase-3, caspase-7, and parp. Rosiglitazone also moderated the dissipation of mitochondrial membrane potential caused by TNF-α treatment and reduced the expression of bax and the release of cytochrome c. Furthermore, rosiglitazone inhibited phosphorylations of ERK/MAPK and NF-κB signal molecules. Both ERK and NF-κB inhibitors decreased TNF-α-induced apoptosis of EPCs, as well as the expression of cleaved caspase-3 and parp. These results suggest that rosiglitazone may mediate the inhibitory effect on EPCs apoptosis under TNF-α stimulation through suppression of ERK/MAPK and NF-κB signal pathways.

show abstract

“…A ging is associated with increased inflammatory activity (1,2). Serum Creactive protein (CRP) is a sensitive marker of systemic low-grade inflammation and is an important predictor of type 2 diabetes (3,4) and cardiovascular disease (CVD) (5).…”

mentioning

confidence: 99%