Agenesis of the Corpus Callosum: A Literature Review

Tu, Shihfen; Doherty, D.; Schilmoeller, Kathryn J.; Schilmoeller, Gary L.

doi:10.1016/s0074-7750(08)38007-0

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…A common neurological issue is seizures, which usually have an early onset, though AgCC does not necessarily cause seizures (Unterberger et al, 2016). Approximately 60% to 80% of individuals with AgCC were reported to have developmental delays, especially in gross and fine motor skills such as clumsiness, delayed walking, and dexterity (Tu et al, 2009). Language delays and difficulty with interpersonal skills, understanding social cues, metaphors, humor, and emotional reciprocity are prevalent (Brown et al, 2021;Lau et al, 2013;Tu et al, 2009).…”

Section: Symptomsmentioning

confidence: 99%

“…Approximately 60% to 80% of individuals with AgCC were reported to have developmental delays, especially in gross and fine motor skills such as clumsiness, delayed walking, and dexterity (Tu et al, 2009). Language delays and difficulty with interpersonal skills, understanding social cues, metaphors, humor, and emotional reciprocity are prevalent (Brown et al, 2021;Lau et al, 2013;Tu et al, 2009). Increased sensitivity to touch or lowered pain perception is also common (Doherty et al, 2006).…”

Section: Symptomsmentioning

confidence: 99%

“…Placement decisions based more on unique learning needs and less on sociocultural variables and capacity limitations can lead to greater academic, communication, and social outcomes (Agran et al, 2020). Strategic placement decisions and scheduling are important because it is very common for children with AgCC to have difficulty with change (Tu et al, 2009). Therefore, predictability in the learning environment and alerting the student to changes in advance will aid in meeting academic goals.…”

Section: Cognitive/academicmentioning

confidence: 99%

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Agenesis of the corpus callosum.

Simmons,

Watkins,

Presley

2023

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A genesis of the corpus callosum (AgCC) is a rare congenital disorder in which the corpus callosum does not develop properly. The corpus callosum is a band of nerves that serves as a bridge of communication between the left and right hemispheres of the brain. Agenesis refers to the absence or failure of a body part to develop. AgCC is characterized as complete agenesis, partial agenesis, hypoplasia (underdeveloped corpus callosum), or dysgenesis (malformation).

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Section: Symptomsmentioning

confidence: 99%

Section: Symptomsmentioning

confidence: 99%

Section: Cognitive/academicmentioning

confidence: 99%

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Agenesis of the corpus callosum.

Simmons,

Watkins,

Presley

2023

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“…To bridge the gap on how turn-taking might rely on CC interhemispheric connectivity might be best informed by studies on developmental agenesis of the CC. Next to altered language abilities (Bartha-Doering et al, 2021), there are reports on communication deficits that entail pragmatic skills (understanding jokes and non-verbal cues such as emotional vocal and facial expressions; see for example, Brown et al, 2005;Tu et al, 2009). Further, younger children with CC agenesis seem to struggle with initiating and sustaining conversations and lack a basic understanding of social reciprocity and non-verbal communication (Badaruddin et al, 2007).…”

Section: Human Spoken Language and Turn-takingmentioning

confidence: 99%

Interhemispheric Brain Communication and the Evolution of Turn-Taking in Mammals

Ravignani

Lumaca²,

Kotz³

2022

Front. Ecol. Evol.

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In the last 20 years, research on turn-taking and duetting has flourished in at least three, historically separate disciplines: animal behavior, language sciences, and music cognition. While different in scope and methods, all three ultimately share one goal—namely the understanding of timed interactions among conspecifics. In this perspective, we aim at connecting turn-taking and duetting across species from a neural perspective. While we are still far from a defined neuroethology of turn-taking, we argue that the human neuroscience of turn-taking and duetting can inform animal bioacoustics. For this, we focus on a particular concept, interhemispheric connectivity, and its main white-matter substrate, the corpus callosum. We provide an overview of the role of corpus callosum in human neuroscience and interactive music and speech. We hypothesize its mechanistic connection to turn-taking and duetting in our species, and a potential translational link to mammalian research. We conclude by illustrating empirical venues for neuroethological research of turn-taking and duetting in mammals.

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“…One of the most common congenital cerebral malformations is agenesis of the corpus callosum (ACC), which is morphologically the full or partial absence of the CC. It is often characterized by functional or behavioral disorders ( Tu et al, 2009 ; Lau et al, 2013 ; Siffredi et al, 2013 ; Edwards et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms of corpus callosum development: a four-step journey

Gavrish,

Kustova,

Celis Suescún

et al. 2024

Front. Neuroanat.

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The Corpus Callosum (CC) is a bundle of axons connecting the cerebral hemispheres. It is the most recent structure to have appeared during evolution of placental mammals. Its development is controlled by a very complex interplay of many molecules. In humans it contains almost 80% of all commissural axons in the brain. The formation of the CC can be divided into four main stages, each controlled by numerous intracellular and extracellular molecular factors. First, a newborn neuron has to specify an axon, leave proliferative compartments, the Ventricular Zone (VZ) and Subventricular Zone (SVZ), migrate through the Intermediate Zone (IZ), and then settle at the Cortical Plate (CP). During the second stage, callosal axons navigate toward the midline within a compact bundle. Next stage is the midline crossing into contralateral hemisphere. The last step is targeting a defined area and synapse formation. This review provides an insight into these four phases of callosal axons development, as well as a description of the main molecular players involved.

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Agenesis of the Corpus Callosum: A Literature Review

Cited by 7 publications

References 34 publications

Agenesis of the corpus callosum.

Agenesis of the corpus callosum.

Interhemispheric Brain Communication and the Evolution of Turn-Taking in Mammals

Molecular mechanisms of corpus callosum development: a four-step journey

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