Agenesis of the Gallbladder with the Presence of a Small Dysmorphic Cyst: Role of Magnetic Resonance Cholangiopancreatography

Pierro, Antonio; Martucci, Matia; Maselli, Giuseppina; Farchione, Alessandra

doi:10.4103/2156-7514.95431

Cited by 11 publications

(13 citation statements)

References 9 publications

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“…MRCP is a noninvasive and well-demonstrated imaging method in the evaluation of the biliary tract [5, 16, 17]. As it does not require contrast administration to visualize the bile, it is not compromised by biliary stasis.…”

Section: Discussionmentioning

confidence: 99%

Agenesis of the Gallbladder: Role of Clinical Suspicion and Magnetic Resonance to Avoid Unnecessary Surgery

Tagliaferri

Bergmann

Hammans

et al. 2017

Case Rep Gastroenterol

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Isolated agenesis of the gallbladder is usually a rare asymptomatic anatomical variation, with an estimated incidence of 10–65 per 100,000. Females are more commonly affected (ratio 3: 1), with the disease typically presenting in the second or third decade of their life. Despite an absent gallbladder, half of the patients present with symptoms similar to biliary colic, which is poorly understood. The rarity of this condition combined with its clinical and radiological features often lead to a wrong preoperative diagnosis so that many patients undergo unnecessary operative intervention. Herein, we present the case of a 56-year-old female with a typical biliary colic who was diagnosed to have gallbladder agenesis. Computed tomography and magnetic resonance cholangiopancreatography allowed correct treatment and prevented an unnecessary intervention.

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Section: Discussionmentioning

confidence: 99%

Agenesis of the Gallbladder: Role of Clinical Suspicion and Magnetic Resonance to Avoid Unnecessary Surgery

Tagliaferri

Bergmann

Hammans

et al. 2017

Case Rep Gastroenterol

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“…In symptomatic patients, the most common clinical presentation is right upper-quadrant pain mimicking biliary colic. The cause of biliary colic in patients with an absent gall bladder is attributed to sphincter of Oddi dysfunction and biliary dyskinesia, which in turn promotes biliary stasis, infection, and choledocholithiasis [ 12 – 14 ].…”

Section: Discussionmentioning

confidence: 99%

Gall Bladder Agenesis: A Rare Embryonic Cause of Recurrent Biliary Colic

Rajkumar¹,

Piya²

2017

Am J Case Rep

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Patient: Female, 24Final Diagnosis: Gallbladder agenesisSymptoms: —Medication: —Clinical Procedure: —Specialty: Gastroenterology and HepatologyObjective:Rare diseaseBackground:Gallbladder agenesis (GA) is an extremely rare anatomic anomaly with a reported incidence of less than 0.5%. It is usually asymptomatic, but can present with features of biliary colic and cholecystitis. We present here a case of GA in a patient with recurrent biliary colic.Case Report:A 24-year-old African American woman presented with recurrent episodes of right upper-quadrant abdominal pain. During her first episode, she was found to have elevated transaminases and clinical features of cholecystitis, but ultrasound did not visualize a gallbladder and she was discharged with a diagnosis of biliary colic. She returned within a week with worsening liver enzymes, severe pain, and vomiting. A hepatobiliary iminodiacetic acid (HIDA) scan was done, which again did not show the gall bladder. On clinical suspicion of acute cholecystitis, she underwent laparoscopic surgery. Intraoperatively, the gall bladder fossa was empty and a diagnosis of gall bladder agenesis was made. She presented a third time with similar complaints and magnetic resonance cholangiopancreatography (MRCP) was done, which showed normal biliary tract anatomy and absent gall bladder. A diagnosis of sphincter of Oddi dysfunction was made and she was discharged on antispasmodics.Conclusions:Diagnosing GA is challenging. The rarity of this entity combined with classic clinical features of cholecystitis and non-visualization of the gall bladder on routine investigation prompts unnecessary surgical intervention. Awareness of this condition, along with use of better imaging modalities like preoperative MRCP, can aide physicians to appropriately manage this uncommon clinical condition.

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“…Peroral cholangioscopy, however, clearly showed it, absolutely different from the dysmorphic cyst of Pierro et al [20], to be the crescent-folded cul-de-sac originating from and running cephalad parallel with the mid extrahepatic bile duct, definitely revealing it to be the hypogenetic cystic duct, the vestige of the abortive primordium which should have developed into the full-fledged cystic duct and gallbladder. Thus it thoroughly confirmed the preoperative diagnosis and ruled out the possibility of choledochal cyst.…”

Section: Congenital Agenesis Of the Gallbladder With The Hypogenetic mentioning

confidence: 69%

Congenital Agenesis of the Gallbladder with the Hypogenetic Cystic Duct Definitely Diagnosed by Peroral Cholangioscopy

Sasaki¹

2014

JGPLD

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Agenesis of the Gallbladder with the Presence of a Small Dysmorphic Cyst: Role of Magnetic Resonance Cholangiopancreatography

Cited by 11 publications

References 9 publications

Agenesis of the Gallbladder: Role of Clinical Suspicion and Magnetic Resonance to Avoid Unnecessary Surgery

Agenesis of the Gallbladder: Role of Clinical Suspicion and Magnetic Resonance to Avoid Unnecessary Surgery

Gall Bladder Agenesis: A Rare Embryonic Cause of Recurrent Biliary Colic

Congenital Agenesis of the Gallbladder with the Hypogenetic Cystic Duct Definitely Diagnosed by Peroral Cholangioscopy

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