Agenesis of the internal carotid artery: a family pathology?

Perla, Francesco Massimo; Carbotta, Giovanni; Nardo, Dario Di; D'Avanzo, M; Colaiacomo, Maria Chiara; Biasi, C. Di; Falvo, L; Carbotta, Sabino; Maturo, A; Tartaglia, Francesco; Tromba, L

doi:10.11138/gchir/2017.38.1.046

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…While there are important considerations when it comes to frequent imaging including radiation exposure, and patient costs, the benefits of possibly identifying an aneurysm before complications occur should not be overlooked. In a case report by Perla et al, a patient with ICA agenesis was followed for 7 years with annual imaging but no changes were discovered [ 19 ]. Given the nature of agenesis, risk factors such as hypertension, smoking, diabetes, hyperlipidemia, and cardiovascular disease should be closely followed and controlled.…”

Section: Discussionmentioning

confidence: 99%

A Rare and Unusual Cause of Ischemic Stroke to Be Aware of

et al. 2022

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Congenital absence of an internal carotid artery (ICA) is an extremely rare vascular anomaly. This case report presents an instance of right ICA agenesis to highlight the importance of early identification of this anomaly and its impact on disease presentation and complications. With transient ischemic attack (TIA), cerebrovascular accident (CVA), and cerebral aneurysms being among the chief presenting scenarios or course of the anomaly, it is important to have a high level of suspicion for these in patients with known ICA agenesis. Understanding the underlying development of this vasculature and its impact on cerebral circulation aids in identifying possible findings on imaging. This case report aims to delineate the pathophysiology of ICA agenesis, recognition of the vasculature that contributes to the anomaly, different presentations of the disease, complications, and obstacles in management.

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Section: Discussionmentioning

confidence: 99%

A Rare and Unusual Cause of Ischemic Stroke to Be Aware of

et al. 2022

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“…CICAH may be more common than previously thought. Reports often state the prevalence is 0.01%, 4,5,11,17,18 but recent studies suggest that the true prevalence is higher. 9,19,20,21 The underestimate may have prevailed due to the asymptomatic nature of the condition.…”

Section: Prevalencementioning

confidence: 99%

“…The condition reportedly has a prevalence of less than 0.01%. 4,5 CICAH is associated with an increased risk of aneurysm formation, and the associated haemodynamic changes contribute to a thrombophilic environment.…”

Section: Introductionmentioning

confidence: 99%

Congenital internal carotid artery hypoplasia: A systematic review

et al. 2022

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This review evaluates the current evidence for the clinical management of congenital internal carotid artery hypoplasia (CICAH). We summarise clinical presentations diagnostic standards, imaging recommendations, treatment and follow-up. The review was prompted by a case of CICAH in a 50-year-old female who presented to our neurosurgery clinic with an acute episode of vertigo. The patient underwent CT angiogram, which showed an unusually low right carotid bifurcation. The right internal carotid artery (ICA) was hypoplastic, and the A1 segment of the anterior cerebral artery (ACA) was absent. Skull base CT showed an ipsilateral hypoplastic carotid canal. To summarise current evidence for clinical management of CICAH we followed PRISMA guidelines to identify papers meeting our predefined inclusion criteria. We searched three databases using the terms ‘ICA’ and ‘Hypoplasia’. We reviewed 41 papers meeting our criteria. 34 were clinical reports. We performed a data extraction and quality appraisal on these reports. We found that CICAH may be less rare than previously described. Blood pressure control in CICAH is crucial due to the increased risk of stroke and aneurysm formation. Follow-up imaging is strongly recommended. Carotid doppler sonography is a powerful and underutilised diagnostic tool, and carotid canal hypoplasia is not a pathognomic sign. In conclusion, clinicians should be alert to anatomic variations such as CICAH because these produce haemodynamic changes that may have serious clinical consequences. We recommend a central registry of patients with CICAH in order to understand the longer-term natural history of the condition.

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“…We define the agenesis of the Internal Carotid Artery (ICA) as a congenital absence of the ICA, it is very rare (less than of 0.01% of the population) [1] and is usually incidental on finding, the patients with this condition are usually asymptomatic because of a collateral pathway that develops in response [2] . This provides adequate irrigation to maintain normal cerebral function.…”

Section: Introductionmentioning

confidence: 99%

Agenesis of the internal carotid artery: a family pathology?

Cited by 11 publications

References 8 publications

A Rare and Unusual Cause of Ischemic Stroke to Be Aware of

A Rare and Unusual Cause of Ischemic Stroke to Be Aware of

Congenital internal carotid artery hypoplasia: A systematic review

Agenesis of the right internal carotid artery associated with ipsilateral Raeder syndrome, first case report

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