Agent in Urgent Need of Clinical Practice: Corilagin

Abstract

Corilagin is a naturally occurring water-soluble retrogallic acid tannin, which can be extracted from many kinds of plants. Known at present, it is the main effective ingredient of Phyllanthus urinaria L., Geranium wilfordii Maxim., Phyllanthus matsumurae Hayata, Trifolium repens L.. It also exists in Phyllanthus emblica L., Dimocarpus longan Lour., Canarium album (Lour.) Raeusch., and Terminalia chebula Retz.. It can participate in a variety of signaling pathways in vivo and has multiple biological activities, including antitumor, anti-microbial, anti-oxidation, anti-inflammation, hepatoprotective, anti-allergy, anti-proliferation and so on. Given the limited efficacy of first-line treatments for many diseases such as oncology, chronic liver disease, and rheumatic immune system diseases, and the potential for adverse effects to outweigh the therapeutic effects, attention is being focused on alternative treatments, and natural plant extracts are a natural target for alternative treatments, as natural substances tend to have low toxicity to normal tissues. Some proprietary Chinese medicines containing corilagin have been used in clinical applications, being clinically applied to treat chronic liver disease, viral hepatitis B, rheumatoid arthritis and other diseases. This paper reviews the extraction, determination, distribution and harvesting, pharmacokinetics, biological activity, safety assessment of corilagin and its application in clinical practice.

Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78

“…Moreover, since natural substances tend to have low toxicity to normal tissues, natural plant extracts are natural targets for alternative therapies. Some proprietary Traditional Chinese medicines containing Corilagin have been used in clinical applications for the treatment of rheumatoid arthritis, viral hepatitis B, chronic liver disease and other diseases 33 . However, there are no previous toxicity studies related to HCT-8 cell viability, and the effects and mechanisms of pro-apoptosis in CRC cells have not been clarified.…”

Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

“…Other polyphenolic compounds can be found in F. virosa, notably the common dietary flavonol rutin [151]; the ellagitannins corilagin, acalyphidin M and geraniin; the gallic acid derivative glucogallin [109]; and (2S,3R)-4E-dehydrochebulic acid trimethyl ester [152]. These natural products, which are often present in natural medicines, are potent antioxidant compounds [153]. Corilagin is well recognized for its anticancer effects [154,155] and its anti-inflammatory effects [153].…”

“…These natural products, which are often present in natural medicines, are potent antioxidant compounds [153]. Corilagin is well recognized for its anticancer effects [154,155] and its anti-inflammatory effects [153].…”