Agentes terapéuticos utilizados en 238 pacientes hospitalizados por COVID-19 y su relación con la mortalidad

Rivera-Izquierdo, Mario; Valero-Ubierna, María del Carmen; R-delAmo, Juan Luis; Fernández-García, Miguel; Martínez-Diz, Silvia; Tahery-Mahmoud, Arezu; Rodríguez-Camacho, Marta; Gámiz-Molina, Ana Belén; Barba-Gyengo, Nicolás; Gámez-Baeza, Pablo; Cabrero-Rodríguez, Celia; Guirado-Ruiz, Pedro Antonio; Martín-Romero, Divina Tatiana; Ramos‐Bossini, Antonio Jesús Láinez; Sánchez-Pérez, María Rosa; Mancera-Romero, José; García‐Martín, Miguel A.; Martín-delosReyes, Luis Miguel; Martínez-Ruiz, Virginia; Jiménez-Mejías, Eladio

doi:10.1016/j.medcli.2020.06.025

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…7 Unidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, Córdoba, Spain. 8 Instituto Maimónides de Investigación Biomédica de Córdoba (Imibic), Córdoba, Spain. 9 Chair of Teaching and Research in Family Medicine, SEMERGEN-UGR, University of Granada, Granada, Spain.…”

Section: Acknowledgementsunclassified

“…This progression led to a significant number of severe cases that required hospitalization and intensive care [3]. Immediately, major efforts were made internationally in order to identify the main symptoms to optimize diagnosis [4][5][6] and the main prognostic factors to improve treatment and healthcare strategies [7][8][9][10]. A wide and multifaceted range of clinical manifestations was identified, including respiratory, gastrointestinal, neurological and cardiovascular symptoms, among others [11].…”

Section: Introductionmentioning

confidence: 99%

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Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Romero-Duarte

Rivera-Izquierdo

Alba

et al. 2021

BMC Med

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134

115

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Background Long-term effects of COVID-19, also called Long COVID, affect more than 10% of patients. The most severe cases (i.e. those requiring hospitalization) present a higher frequency of sequelae, but detailed information on these effects is still lacking. The objective of this study is to identify and quantify the frequency and outcomes associated with the presence of sequelae or persistent symptomatology (SPS) during the 6 months after discharge for COVID-19. Methods Retrospective observational 6-month follow-up study conducted in four hospitals of Spain. A cohort of all 969 patients who were hospitalized with PCR-confirmed SARS-CoV-2 from March 1 to April 15, 2020, was included. We collected all the SPS during the 6 months after discharge reported by patients during follow-up from primary care records. Cluster analyses were performed to validate the measures. The main outcome measures were return to the Emergency Services, hospital readmission and post-discharge death. Surviving patients’ outcomes were collected through clinical histories and primary care reports. Multiple logistic regression models were applied. Results The 797 (82.2%) patients who survived constituted the sample followed, while the rest died from COVID-19. The mean age was 63.0 years, 53.7% of them were men and 509 (63.9%) reported some sequelae during the first 6 months after discharge. These sequelae were very diverse, but the most frequent were respiratory (42.0%), systemic (36.1%), neurological (20.8%), mental health (12.2%) and infectious (7.9%) SPS, with some differences by sex. Women presented higher frequencies of headache and mental health SPS, among others. A total of 160 (20.1%) patients returned to the Emergency Services, 35 (4.4%) required hospital readmission and 8 (1.0%) died during follow-up. The main factors independently associated with the return to Emergency Services were persistent fever, dermatological SPS, arrythmia or palpitations, thoracic pain and pneumonia. Conclusions COVID-19 cases requiring hospitalization during the first wave of the pandemic developed a significant range of mid- to long-term SPS. A detailed list of symptoms and outcomes is provided in this multicentre study. Identification of possible factors associated with these SPS could be useful to optimize preventive follow-up strategies in primary care for the coming months of the pandemic.

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Section: Acknowledgementsunclassified

Section: Introductionmentioning

confidence: 99%

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Romero-Duarte

Rivera-Izquierdo

Alba

et al. 2021

BMC Med

Self Cite

134

115

View full text Add to dashboard Cite

show abstract

“…Algunas variables de potencial interés, tales como la obesidad, hábitos tóxicos o nivel socioeconómico no estaban sistemáticamente recogidas, por lo que no pudieron evaluarse en este estudio, tal como ocurre en otros estudios con análisis multivariantes realizados en nuestro medio (12,23,24). Futuros estudios multicéntricos ( 25) que solventen los citados problemas en diferentes contextos y países servirán para poder corroborar nuestros resultados.…”

Section: Limitaciones Y Retos Para El Futurounclassified

Factors associated with mortality and sequelae in patients living in long-term facilities hospitalized for COVID-19: a longitudinal 6-month follow-up study

Rivera-Izquierdo¹,

Romero-Duarte²,

Cárdenas-Cruz³

2021

Actual. Med.

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Objectives: To evaluate the main factors associated with prognosis (mortality, sequelae at 6 months and readmissions) of patients admitted for COVID-19 at the Hospital Clínico San Cecilio who live in a long-term care facility. Methods: Longitudinal observational study carried out on the cohort of 441 patients admitted for COVID-19 confirmed by PCR at the Hospital Clínico San Cecilio between 01/03/20 and 15/04/20. These patients were followed up, through their medical records, for 6 months after discharge. Sociodemographic, admission, clinical, therapeutic and sequelae variables were collected. Descriptive and bivariate analyses and multivariate logistic regression models were performed with R statistical software, through its R Commander tool. Results: The mean age of the cohort was 66.4 years (s=15.3), with 55.1% male. In-hospital mortality was 18.1%. Patients living in nursing homes had higher mean age and higher frequencies of comorbidities, mortality and hospital readmissions. During the 6 months after discharge, they had a high frequency of sequelae (59%), and a higher frequency of confusion, hematologic and nephrological problems, and superinfections. The main factors associated with mortality were advanced age, male sex, admission to the ICU and vulnerability at admission measured with clinical prognostic scales. Conclusions: Living in a long-term care facility was not an independent factor of mortality, but it did bring together a group of special vulnerability to COVID-19. The causes of mortality analysed in this study could be similar to the causes of mortality of elderly people in nursing homes during the first months of the pandemic. These data should serve to optimize strategies for in-hospital management and follow-up of the elderly during the months following hospital discharge, and to try to reduce the unrecorded mortality due to COVID-19 in this population.

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Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study

et al. 2021

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Objective To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality. Methods A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality. Results A prolonged QTc interval >450 ms was found in 27% of patients admitted with SARS-CoV-2 infection. These patients were predominantly older, on a ventilator, and had hypertension, diabetes mellitus, or ischemic heart disease. They also had high troponin and D-dimer concentrations. A prolonged QTc interval had a significant association with the requirement of ventilator support and was associated with an increased odds of mortality. Patients who died were older than 55 years, and had high troponin, D-dimer, creatinine, procalcitonin, and ferritin concentrations, a high white blood cell count, and abnormal potassium concentrations (hypo- or hyperkalemia). Conclusions A prolonged QTc interval is common in patients with SARS-CoV-2 infection and it is associated with worse outcomes. Older individuals and those with comorbidities should have an electrocardiogram performed, which is noninvasive and easily available, on admission to hospital to identify high-risk patients.

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Agentes terapéuticos utilizados en 238 pacientes hospitalizados por COVID-19 y su relación con la mortalidad

Cited by 6 publications

References 39 publications

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Factors associated with mortality and sequelae in patients living in long-term facilities hospitalized for COVID-19: a longitudinal 6-month follow-up study

Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study

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