Agents for treatment of carciovascular illnesses. III. Antianginal and cardiotonic agents (review)

Liberman, S. S.; Yakhontov, L. N.

doi:10.1007/bf00763655

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2014

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(2 citation statements)

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“…Note that aminoalcohols can be successfully nitrated either with concentrated HNO 3 or its mixture with con centrated H 2 SO 4 with their v/v ratio 1 : (2)(3)(4)(5). Better re sults were obtained with the 1 : (2-3) wt/v ratio of amide and a nitrating agent.…”

Section: Resultsmentioning

confidence: 96%

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Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides

et al. 2014

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A number of dicarboxylic N (2 nitroxyalkyl)amides and N (2 nitroxyalkyl)imides were synthesized and their antiischemic activity was studied. The ratio of the areas of necrotic and ischemic zones was used as a criterion for evaluation of antiischemic activity. The maximum values were close to antiischemic activity of Nicorandil, with acute toxicity of compounds synthesized being considerably lower.Key words: reaction of diethyl dicarboxylates with amino alcohols, nitration of oxyalkyl amides and imides with nitric acid and its mixtures with sulfuric acid and acetic anhydride, solutions of nitric acid in chloroalkanes, succinic and citric nitroxyalkylamides, succinic nitr oxyalkylimides, acute toxicity, antiischemic activity.

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Section: Resultsmentioning

confidence: 96%

“…Compound 8 (6.82 g, 68.1%) was obtained after evaporation of ethyl acetate at reduced pressure, m.p. 100-101 5. C (chloro form).…”

mentioning

confidence: 99%

Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides

et al. 2014

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show abstract

Agents for treatment of carciovascular illnesses. III. Antianginal and cardiotonic agents (review)

Cited by 1 publication

References 27 publications

Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides

Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides

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