2016
DOI: 10.15171/apb.2016.075
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Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer

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Cited by 13 publications
(18 citation statements)
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“…So, this is a method to achieve a well‐defined shape and size of the SD aggregates. The method does not require a bridging agent or a mixed solvent in this aggregation process . Rhombic aggregates and rod‐like aggregates were successfully prepared by this method.…”
Section: Resultsmentioning
confidence: 99%
“…So, this is a method to achieve a well‐defined shape and size of the SD aggregates. The method does not require a bridging agent or a mixed solvent in this aggregation process . Rhombic aggregates and rod‐like aggregates were successfully prepared by this method.…”
Section: Resultsmentioning
confidence: 99%
“…When comparing the different solvents, the factors that can strongly influence the nucleation rate are the supersaturation and the change in the interfacial free energy, γ, that appears as the third power in the exponential term. In classical nucleation theory, according to the Gibbs-Thomson equation, interfacial free energy impacts on the nucleation rate J: 20 J = A.exp(-∆Gc) with ∆Gc = 16πγ 3 V 2 0 /3k 3 BT 3 ln(S*) 2 Eqn 1.…”
Section: Discussionmentioning
confidence: 99%
“…The role of solvent is well established in crystallization (for example Mirmehrabi et al 1 ) and the use of anti-solvents is one of the most common crystallization methods in the pharmaceutical industry. 2,3 A key feature of using anti-solvents is that they increase nucleation rates due to a higher driving force (caused by the lower solubility in the anti-solvent). However, the role of solvent other than its role in creating driving force is only little studied.…”
Section: Introductionmentioning
confidence: 99%
“…Drug release was affected by many reasons, such as drug crystallinity, the size and shape of the crystal. 38 According to Fig. 7, it can be concluded that there are still crystals in the SD(HME).…”
Section: Physical Characteristicsmentioning
confidence: 95%