Agglomeration of Mesoporous Silica by Melt and Steam Granulation. Part I: A Comparison Between Disordered and Ordered Mesoporous Silica

Agglomeration of Mesoporous Silica by Melt and Steam Granulation. Part II: Screening of Steam Granulation Process Variables Using a Factorial Design

“…This observation was also reported in part I but does not occur with experiment 3 where a faster release profile was observed (Fig. a) …”

“…Part I of this study revealed that steam-granulated material 244/PVP/MCC (6/3/1, w/w/w) resulted in a bimodal distribution. 14 The first was at around 3 :m, which is associated with D 50 particle size of 244 starting material (Grace Davison specifications). The second, a broad distribution, revealed a D 50 value around 200 :m, associated with the granulated material.…”

“…We demonstrated in part I of this study that both melt and steam granulation are capable of processing mesoporous silica with little or no PDR. 14 However, X-ray powder diffraction (XRPD) results show that PDR of itraconazole (ITZ) was most prevalent in melt-granulated samples and that degradation of the binder, Poloxamer 188, occurred during the process itself. Also, steam granulation with polyvinylpyrrolidone K25 (PVP) resulted in the overall largest granules.…”

A pilot analysis of morphometric assessment of itraconazole brands using dermoscopy and its relevance in the current scenario

“…The fast-dissolving polymers provide a supersaturated solution of ITZ, from which enhanced absorption is expected. [ 8 10 ] For ITZ–HPMC mixture, the ideal ratio of drug to polymer is about 40:60. [ 11 ] A higher ratio may hamper release of the drug, whereas a lower may cause ineffective and unstable binding.…”

“…[ 7 ] Furthermore, pellet size variability should be minimal, as this reflects an optimum drug: solvent ratio and is a surrogate marker of the manufacturing quality. [ 8 ] A recent article has studied the effect of these variables on the drug dissolution rate, using two different bead–solvent pairs, although in most places only the sucrose beads’ formulation is currently available. [ 9 ]…”