Aggravation of Airway Inflammation in RSV-Infected Asthmatic Mice Following Infection-Induced Alteration of Gut Microbiota

Wang, Jing; Lu, Huina; Yu, Lingxue; Cheng, Weiwei; Yan, Wuning; Jing, Xiaoping

doi:10.22541/au.160253797.76907107/v1

Cited by 1 publication

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References 34 publications

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“…Dzidic et al [38] used Illumina 16S rDNA gene sequencing to characterize saliva samples from allergic and healthy children and found that Prevotellaceae were increased in allergic children. Wang et al [39] investigated the relationship between IgE and asthma, using ELISA and 16S rRNA sequencing to investigate the relationship between IgE and gut microbiota.…”

Section: Scfa Contentsmentioning

confidence: 99%

Whey protein hydrolysates alleviated food allergy in mice by balancing the Th1/Th2 pathway and increasing IgA antibody production

Yin,

Guo,

Hong

et al. 2023

Food Science of Animal Products

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Whey protein, a by-product of cheese processing, is ubiquitously applied in infant formula. Nevertheless, it contains β-lactoglobulin, an allergenic component that can be enzymatically hydrolyzed to destroy its allergenic epitopes and antigenicity. The whey protein hydrolysate (WPH) obtained through enzymatic hydrolysis exhibits a wide range of biological activities. However, its utilization in preventing whey protein food allergies has received limited research attention. This study aimed to examine the preventive effect of WPH intervention on whey protein-induced food allergy in BALB/c mice. The results showed that WPH intervention notably mitigated the development of allergic reactions in mice with whey protein-induced food allergies. The intervention with WPH significantly reduced the symptom score of allergic reactions in mice with whey protein-induced food allergies (39.38%, P < 0.01). Early intervention with WPH also led to a significant reduction in the serum levels of antibodies and related cytokines, including IgE, histamine, IgG, and monocyte chemotactic protein-1 (MCP-1) in mice (P < 0.05). A potential mechanism for alleviating allergic reactions was identified from the proteomic findings. WPH was found to upregulate the Th1 differentiation pathway and IgA secretion pathway by increasing MHC II protein expression, thereby alleviating allergic reactions to whey protein in food. Regarding the gut microbiome, WPH intervention led to a decrease in the relative abundance of harmful bacteria, including Prevotellaceae_UCG-001, and Alloprevotella (5.4% and 2.3%, respectively; P< 0.05). It increased the relative abundance of beneficial bacteria such as Turicibacter, Roseburia, and Alistips (3.8%, 0.6%, and 1.4%, respectively; P < 0.05). The present study suggests early WPH intervention may attenuate whey protein-induced food allergic reactions.

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Section: Scfa Contentsmentioning

confidence: 99%

Whey protein hydrolysates alleviated food allergy in mice by balancing the Th1/Th2 pathway and increasing IgA antibody production

Yin,

Guo,

Hong

et al. 2023

Food Science of Animal Products

View full text Add to dashboard Cite

show abstract

Aggravation of Airway Inflammation in RSV-Infected Asthmatic Mice Following Infection-Induced Alteration of Gut Microbiota

Abstract: This a preprint and has not been peer reviewed. Data may be preliminary.

Cited by 1 publication

References 34 publications

Whey protein hydrolysates alleviated food allergy in mice by balancing the Th1/Th2 pathway and increasing IgA antibody production

Whey protein hydrolysates alleviated food allergy in mice by balancing the Th1/Th2 pathway and increasing IgA antibody production

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