Aggravation of Thiamine Deficiency by Magnesium Depletion: <i>A Case Report</i>

Dyckner, Thomas; Ek, B.; Nyhlin, Henry; Wester, Per‐Olov

doi:10.1111/j.0954-6820.1985.tb08836.x

Cited by 47 publications

(22 citation statements)

References 3 publications

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“…Transketolase requires TPP and magnesium as a cofactor [19]. Case studies suggest that hypomagnesaemia is a potential cause of occasional non‐response to thiamine replacement in some patients with WKS [19–21]. Animal studies confirm that magnesium deficiency interferes with the response to thiamine replacement, and the effect of magnesium deficiency appears to be due to interference with activation to transketolase [18].…”

Section: Discussionmentioning

confidence: 99%

Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital

Dingwall

Delima

Gent

et al. 2015

Drug and Alcohol Review

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Section: Discussionmentioning

confidence: 99%

Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital

Dingwall

Delima

Gent

et al. 2015

Drug and Alcohol Review

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“…Long-standing diarrhea resulted in combined thiamin and magnesium deficiency. Despite massive doses of thiamin administered intravenously, the symptoms of thiamin deficiency could not be relieved until correction of the magnesium deficiency (18). Wernicke encephalopathy, a well known result of thiamin deficiency, has been reported as being induced by magnesium deficiency (19).…”

Section: Discussionmentioning

confidence: 99%

Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

Lonsdale

2006

Evidence-Based Complementary and Alternative Medicine

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Non-caloric nutrients (NCN) are extremely numerous and it is more than obvious that they work in a team relationship. These vitally important interactions are, for the most part, poorly understood. These brief case reports illustrate this in the therapeutic use of thiamin in a clinical setting. The initially abnormal erythrocyte transketolase activity (TKA) and/or the thiamin pyrophosphate effect (TPPE), indicating intracellular cofactor deficiency, usually improves with thiamin administration. Biochemical correction of the abnormality is, however, invariably dependent on the provision of other NCN, especially magnesium. In two patients reported here, this correction required several infusions containing magnesium and other NCN administered intravenously. In a third patient, hemoconcentration associated with an abnormal TPPE was normalized after administration of nutrients that included thiamin and magnesium.

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“…Development of thiamine deficiency occurs mainly in alcoholics and in patients with malabsorption or malnutrition. Several case reports have been published describing vitamin B1 deficiency in patients with Crohn’s disease (CD) [15,16,17]. Hahn et al [15] describe a CD patient on TPN, in whom beriberi and Wernicke’s encephalopathy developed because multivitamin infusions were switched to an oral multivitamin formula.…”

Section: Water-soluble Vitaminsmentioning

confidence: 99%

“…Hahn et al [15] describe a CD patient on TPN, in whom beriberi and Wernicke’s encephalopathy developed because multivitamin infusions were switched to an oral multivitamin formula. Another case report emphasizes the dependence of thiamine on magnesium and states that if thiamine and magnesium are deficient at the same time, both should be substituted simultaneously [16]. …”

Section: Water-soluble Vitaminsmentioning

confidence: 99%

Intestinal Absorption and Vitamin Levels: Is a New Focus Needed?

Vavricka

Rogler

2012

Dig Dis

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Vitamins are micronutrient chemical compounds that cannot be synthesized by an organism but are essential for human metabolism and life. They act as required intermediaries, cofactors or coenzymes in many of the reactions of normal metabolism. In addition, anti-inflammatory effects have been reported for specific vitamins. In inflammatory bowel disease (IBD), vitamin deficiency is often due to malnutrition (due to a decreased food intake) or malabsorption (due to inflamed, malfunctioning mucosa and diarrhea) which results in anemia. Vitamin B₁₂ and folic acid supplementation may be necessary in IBD patients, especially those with Crohn’s disease (CD) with either inflammation of the terminal ileum or after resection of the terminal ileum. It is also recommended during therapy with sulfasalazine as this compound inhibits the absorption of vitamin B₁₂. Patients with high or continuous inflammatory CD activity and frequent therapy with steroids have an increased risk of low bone mineral density and vitamin D deficiency. These should be monitored regularly and vitamin D should be supplemented. In a recent trial, a trend towards a reduced risk of relapses in CD patients treated with vitamin D was reported. Only limited studies and case reports exist on other vitamin deficiencies, e.g. vitamins A, B₁, B₂, niacine, B₆, C, E and K, found in IBD patients. These are summarized in this review. Regular nutritional monitoring in IBD patients is warranted and requires the special attention of treating physicians and dieticians.

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Aggravation of Thiamine Deficiency by Magnesium Depletion: A Case Report

Cited by 47 publications

References 3 publications

Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital

Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital

Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

Intestinal Absorption and Vitamin Levels: Is a New Focus Needed?

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