One of the major challenges being faced by manufacturing companies today is the issue of addressing various aspects of perishable products in a supply chain environment. To address this issue, the integrated lot size problem for a perishable product has been investigated in the present work. The problem is modeled as a single vendor multiple buyer system. A variant of the truckload discount scheme is applied and the proposed model is formulated as a mixed integer program (MIP). The traditional warehouses are replaced by 'cross-docks' and situations in which, cross-docking would be more beneficial are highlighted. The problem of fleet selection is also addressed and various strategies to minimize the vendor cost are also highlighted for centralized and decentralized supply chains.Sensitivity analysis is then carried out on various input parameters such as setup cost at plant, variable transportation cost, fixed transportation cost, setup cost per order, holding cost and, lost cost, which underscores the significant impact of economies of scale in transportation on the total supply chain cost.Analysis of lead time-cost trade-off reveals that alternate modes of transportation could be explored, which significantly reduces the lead time of transportation, thereby minimizing the total supply chain cost.towards sustainability in the global competitive environment [2]. In the current times, the concept of SC network has been shifting from traditional SC environment. Nowadays, SC is an integral system of raw materials, material procurement, suppliers, manufacturing processes, assembly, dispatch, logistics, inventory, cross-docks, warehouses, end customers and, finally recycling of the product [3]. The SC environment is also defined as an effective management of all components / partners related to SC network which include transportation and replenishment of raw materials either inside the manufacturing shop floor or shipment of finished goods along with transportation decisions (mode of shipment, lot size and, fleet selection) for yielding competitive advantages for all individual components / partners [4-5] . SC network design mainly consists of three levels namely strategic, tactical and, operational decisions [6]. Strategic decisions mainly emphasize on production, assembly and, distribution to fulfill the demand of end customers. Tactical decisions describes the management policy for flow of materials, decisions related to various production level, assembly section, inventory control and, lot sizes. Decisions on operational level deals with scheduling of different operations of SC network for making responsive SC design including coordination in logistic network for assuring on time delivery of the product to the end customer at low cost with least environmental impact [7-8]. However, logistic network which is a part of green supply chain network is one of the major challenging tasks for every manufacturing industry.Moreover, perishability is one of the key issues in a supply chain environment. Integration of product...