In a nutshell: Neurological illnesses, which include a wide range of ailments from Parkinson's disease to epilepsy, present considerable problems to the administration of healthcare. The purpose of this abstract is to present an overview of a unique technique called Machine Learning-Enhanced Decision Support (ML-EDS) for Neurological Disorders Management, which aims to improve patient treatment as well as patient outcomes. Within the scope of this investigation, we have suggested a complete ML-EDS framework that integrates cutting-edge machine learning strategies with more conventional approaches to medical treatment. The framework provides a comprehensive solution that makes use of several types of patient data, such as clinical records, neuroimaging data, genetic information, and data from wearable sensors. The Random Forest, Long Short-Term Memory (LSTM), and k-Nearest Neighbours (k-NN) algorithms are integrated into our methodology in order to improve illness progression prediction, seizure event detection, and individualized medication suggestion. In comparison to more conventional approaches, the suggested framework reveals noteworthy advantages. When compared to conventional algorithms, it demonstrates superior accuracy, sensitivity, and specificity in the prediction of illness development. Additionally, its F1 score is significantly higher. In addition, the application of LSTM for the identification of seizure episodes demonstrates the effectiveness of the method in determining crucial occurrences, which in turn enables prompt intervention. The possibility of tailored medical treatment based on k-means clustering is also highlighted in this research. Patients with comparable clinical characteristics can be grouped together to facilitate the development of personalized treatment methods, which can then provide individualized care pathways. The performance evaluation demonstrates that k-NN is capable of making therapy recommendations with high precision, hence contributing to an overall improvement in the health of the patient. Additionally, the proposed framework performs very well in terms of computational efficiency, reducing the amount of time required for both training and prediction, which positions it as a viable option for healthcare applications that are used in the real world. In summation, the use of machine learning in decision support for the management of neurological disorders in healthcare is a ground-breaking strategy that is reshaping the therapeutic landscape. It does this by using the power of machine learning, which enables it to provide more accurate illness progression predictions, rapid seizure event detection, and highly tailored medical care. The findings and efficiency metrics conclusively indicate that this strategy is superior to existing procedures, suggesting a paradigm change in the therapy of neurological disorders.