Aggregation-induced emission-active amino acid/berberine hydrogels with enhanced photodynamic antibacterial and anti-biofilm activity

Xie, Yanyan; Zhang, Yongfeng; Liu, Xiaozhi; Ma, Xiaofang; Qin, Xiao-Tong; Jia, Shiru; Zhong, Cheng

doi:10.1016/j.cej.2020.127542

Cited by 88 publications

(44 citation statements)

References 48 publications

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“…aureus. In addition, after 1 day, there was almost no colony in the spleen and liver of the group treated by PDT, suggesting phototherapy as potent therapy to inhibit internal bacterial infections (Figure D) . H&E-stained images on day 7 exhibited some congestion in the control group, while the other groups showed new fibroblast proliferation and collagen formation in the wound area (Figure E).…”

Section: Photodynamic Therapymentioning

confidence: 96%

Section: Photodynamic Therapymentioning

confidence: 99%

“…In a study, a hybrid hydrogel with AIE performance was constructed through the self-assembly of commercial N -(9-fluorenylmethoxycarbonyl)- l -phenylalanine (Fmoc-F) and BBR. BBR self-assembled into NPs, which dispersed throughout the photodynamically active hydrogel prepared by the self-assembly of Fmoc-F amino acid, endowing the BBR NP-incorporated hydrogel with ROS generation capability for PDT of infected wound (Figure A) . TEM images of the Fmoc-F/BBR hydrogel showed intertwined nanofibers containing BBR-decorated NPs with diameters of ∼10.9 ± 2.3 nm in size (Figure B).…”

Section: Photodynamic Therapymentioning

confidence: 99%

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

et al. 2021

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Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic therapy (PDT) show great application prospects in the prevention of wound infection and promoting wound healing. In addition, hydrogels have shown attractive advantages in the field of wound dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive hydrogels (MPRHs) that integrate the advantages of light and hydrogels are increasingly used in biomedicine, especially in the field of wound repair. However, a comprehensive review of MPRHs for wound regeneration is still lacking. This review first focuses on various types of MPRHs prepared by diverse photosensitizers, photothermal agents (PHTAs) including transition metal sulfide/oxides nanomaterials, metal nanostructure-based PHTAs, carbon-based PHTAs, conjugated polymer or complex-based PHTAs, and/or photodynamic agents (PHDAs) such as ZnO-based, black-phosphorus-based, TiO 2 -based, and small organic molecule-based PHDAs. We also then discuss how PTT, PDT, and photothermal/photodynamic synergistic therapy can modulate the microenvironments of bacteria to inhibit infection. Overall, multifunctional hydrogels with both therapeutic and tissue regeneration capabilities have been discussed and existing challenges, as well as future research directions in the field of MPRHs and their application in wound management are argued.

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Section: Photodynamic Therapymentioning

confidence: 96%

Section: Photodynamic Therapymentioning

confidence: 99%

Section: Photodynamic Therapymentioning

confidence: 99%

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

et al. 2021

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“…Recently, bacteriophage-based treatments are proposed to eradicate biofilms and one can design effective phage-based strategies upon understanding phage-biofilms interactions [182]. Photodynamic therapy is yet another strategy that has been proven as effective in inhibiting biofilm in wounds and also eradicating planktonic cells [183,184].…”

Section: Recent Developments In Eradication Of Biofilms In the Health And Food Sectormentioning

confidence: 99%

Microbial biofilm: A matter of grave concern for human health and food industry

et al. 2021

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Pathogenic microorganisms have adapted different strategies during the course of time to invade host defense mechanisms and overcome the effect of potent antibiotics. The formation of biofilm on both biotic and abiotic surfaces by microorganisms is one such strategy to resist and survive even in presence of antibiotics and other adverse environmental conditions. Biofilm is a safe home of microorganisms embedded within self‐produced extracellular polymeric substances comprising of polysaccharides, extracellular proteins, nucleic acid, and water. It is because of this adaptation strategy that pathogenic microorganisms are taking a heavy toll on the health and life of organisms. In this review, we discuss the colonization of pathogenic microorganisms on tissues and medically implanted devices in human beings. We also focus on food spoilage, disease outbreaks, biofilm‐associated deaths, burden on economy, and other major concerns of biofilm‐forming pathogenic microorganisms in food industries like dairy, poultry, ready‐to‐eat food, meat, and aquaculture.

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“…Among the edible plants containing alkaloids are Berberis species containing the well-known alkaloid berberine [197]. The light-dependent antibacterial properties of this compound have been demonstrated as effective against Gram-positive S. aureus and Gram-negative E. coli [198][199][200] (Table 3).…”

Section: Riboflavinmentioning

confidence: 99%

Antimicrobial Effect of Phytochemicals from Edible Plants

Hochma

Yarmolinsky²,

Khalfin

et al. 2021

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Current strategies of combating bacterial infections are limited and involve the use of antibiotics and preservatives. Each of these agents has generally inadequate efficacy and a number of serious adverse effects. Thus, there is an urgent need for new antimicrobial drugs and food preservatives with higher efficacy and lower toxicity. Edible plants have been used in medicine since ancient times and are well known for their successful antimicrobial activity. Often photosensitizers are present in many edible plants; they could be a promising source for a new generation of drugs and food preservatives. The use of photodynamic therapy allows enhancement of antimicrobial properties in plant photosensitizers. The purpose of this review is to present the verified data on the antimicrobial activities of photodynamic phytochemicals in edible species of the world’s flora, including the various mechanisms of their actions.

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Aggregation-induced emission-active amino acid/berberine hydrogels with enhanced photodynamic antibacterial and anti-biofilm activity

Cited by 88 publications

References 48 publications

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

Microbial biofilm: A matter of grave concern for human health and food industry

Antimicrobial Effect of Phytochemicals from Edible Plants

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