Aggregation of Blood Cells by 5-Hydroxytryptamine (Serotonin)

Swank, Roy L.; Fellman, J.H.; Hissen, W

doi:10.1161/01.res.13.5.392

Cited by 51 publications

(12 citation statements)

References 3 publications

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“…It increases blood viscosity [6] and plays a role in platelet aggregation [7]. It has a complex influence on vasoconstriction and vasodilatation [8,9], Furthermore, it enhances peripheral microvascular permeability and thus plays a role in the development of oedema [10].…”

Section: Introductionmentioning

confidence: 99%

Serotonin (5-HT) and the rat's eye

1992

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Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic amine which has a multitude of more or less clearly established effects on peripheral vessels. It influences blood viscosity, platelet aggregation, and vasoconstruction and -dilatation, it enhances capillary permeability, it is the precursor of melatonin (a hormone with diurnal production in the eye). Because of these actions a role for serotonin in the development of glaucoma and diabetic retinopathy might be suspected. In a series of pilot studies on rats the effects of serotonin on the anterior and posterior segments of the eye were studied. Serotonin had marked influence on the retinal and choroidal vasculature. The optic disk seemed to be very sensitive to serotonin. Possibly it had an influence on the blood-retinal barrier. It caused transient cataracts, probably by decreasing the production of aqueous. It blocked tropicamin-induced mydriasis. The techniques and provisional results of measurement of serotonin in human aqueous are also described.

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Section: Introductionmentioning

confidence: 99%

Serotonin (5-HT) and the rat's eye

1992

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“…In the 1960 s, several investigators established the correlation between platelets, blood cell aggregates, and degradation products during blood perfusion and reported the difficulties experienced with rising perfusion pressure, tissue edema, and impaired function or no function upon reimplantation of the organ [8,16,63,96]. To avoid these difficulties, plasma was selected as a perfusate.…”

Section: Vascular Integrity During Warm Temperature Perfusionmentioning

confidence: 99%

“…They additionally perfused kidneys for at least 24 h without reimplantation, suggesting the feasibility of prolonged warm perfusion by diluting the perfusate with a balanced salt solution and adding low molecular weight dextran. Thus, although some obstacles were overcome, physiological studies using the isolated kidney perfusions with blood had their limitations, including brevity of the steady-state period, low glomerular filtration rates, abnormal tubular functions, alterations in intrarenal blood flow distribution, and limited duration of survival [39,72].In the 1960 s, several investigators established the correlation between platelets, blood cell aggregates, and degradation products during blood perfusion and reported the difficulties experienced with rising perfusion pressure, tissue edema, and impaired function or no function upon reimplantation of the organ [8,16,63,96]. To avoid these difficulties, plasma was selected as a perfusate.…”

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confidence: 99%

Kidney preservation in the next millenium

Stubenitsky¹,

Booster²,

Nederstigt³

et al. 1999

Transplant International

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For the past decades, severe hypothermia has represented the foundation of organ preservation in clinical transplantation. Beneficial as hypothermia has proven to be in preserving grafts from heart-beating donors, hypothermia does not seem to provide the window necessary for the prospective evaluation of organ function. With the increasing use of non-heart-beating donors, it is logical to propose that if organs are to be evaluated prospectively, it will be necessary to preserve them at warmer temperatures. Since both glomerular and tubular functions are inhibited at temperatures below 18 degrees C, such a goal will necessitate organ preservation at a temperature above 20 degrees C. The principle of preservation at warmer temperatures is not new, but with future developments and approaches, successful realization appears within reach. In this overview, a brief history of previous attempts at warm preservation, in the context of the current status of kidney preservation, is presented. Future developments and approaches, with the potential for prospective testing of the function and enhanced resistance to ischemic damage, will be discussed.

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“…91 While suppression of some serotonin functions by heparin has been demonstrated in vitro, 48 there is less clear evidence in vivo. 52,81 This is in part due to the frequently unpredictable manner in which serotonin will act even in the same species, and because tachyphylaxis develops easily. 62 The implication of serotonin in the pathophysiology of migraine is accepted by the majority of students of migraine, 17,18 but controversy exists between investigators with regard to its precise effect.…”

Section: Commentsmentioning

confidence: 99%

Heparin in Migraine Headache

Thonnard-Neumann¹

1973

Headache

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Aggregation of Blood Cells by 5-Hydroxytryptamine (Serotonin)

Cited by 51 publications

References 3 publications

Serotonin (5-HT) and the rat's eye

Serotonin (5-HT) and the rat's eye

Kidney preservation in the next millenium

Heparin in Migraine Headache

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