Aggregation of dextran hydrophobically modified by sterically hindered phenols

Filippov, Sergey K.; Komolov, A. S.; Sergeeva, O. Yu.; Olifirenko, A. S.; Lesnichin, Stepan B.; Komarova, E. A.; Логинов, Б. А.; Домнина, Н. С.; Лезов, А. В.

doi:10.1134/s0965545x09020035

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…The resulting molecular characteristics of the conjugates can be compared with the research results on the aqueous solutions of dextran-SHP2 and polyvinyl alcohol-SHP2 conjugates [4,7]. The solutions of these compounds were also found to contain single molecules and aggregates, the fraction of which was 1% or less.…”

Section: Resultsmentioning

confidence: 99%

“…Researchers have so far determined and studied in detail the molecular and antioxidant characteristics of dextran-and polyvinyl alcohol-based HMAOs using the derivatives of sterically hindered phenols (SHPs). The antiradical activity of SHPs has been found to increase dramatically when they are added to the polymer backbone [3][4][5][6]. In this context, the search for polymers that could serve as a basis of HMAOs is of considerable interest.…”

Section: Introductionmentioning

confidence: 99%

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Molecular characteristics and antioxidant activity of polyethylene glycols modified by sterically hindered phenols

et al. 2011

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Chemical modification of polyethylene glycols by antioxidants belonging to the class of sterically hindered phenols is used to obtain water-soluble conjugates differing in the structure of the joined antioxidant and molecular weight. The inclusion of hydrophobic end groups in polyethylene glycol molecules leads to a decrease in the lower critical mixing point of the solution as compared to the original polymer. Dilute solution viscometry and light scattering are used to determine the molecular-mass characteristics of the polymers and the hydrodynamic radii of single conjugate molecules. The mass fraction of single molecules in aqueous solutions of the conjugates is greater than 95%. The aggregates are micellar-type particles whose core is formed by the hydrophobic moieties of sterically hindered phenols. It is shown that the antiradical activity of the antioxidants 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)-propionic acid and 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionic acid, which are used for the modification, differs only slightly, whereas the activity of the relevant conjugates increases significantly.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular characteristics and antioxidant activity of polyethylene glycols modified by sterically hindered phenols

et al. 2011

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“…To create HMAO, we used the method of chemical modification of hydrophilic polymers with various antioxidants, making possible a targeted design of the macromolecular systems with antioxidant properties 62‐80,83‐89,99‐101 …”

Section: Introductionmentioning

confidence: 99%

“…The high antiradical activity of HMAOs in water, their polymeric nature, and the potential application of HMAOs in medicine demands the importance to study their behavior in water and in aqueous media 68,74,75,86‐89,71,79‐81 …”

Section: Introductionmentioning

confidence: 99%

“…Indeed, intrinsic viscosity [ η ] is reversely to the particle's density:

([], η) \sim (\frac{R_{g}^{3}}{M_{w}})

. If any compaction of a macromolecule occurred in solution, it should be manifested by a decrease in intrinsic viscosity value as it was observed for PVA and PEG‐based HMAOs 80,86‐88 . Therefore, viscometry gives although indirect but useful insight on the behavior of macromolecules in solution.…”

Section: Introductionmentioning

confidence: 99%

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Future and the past of polymeric antioxidants

Filippov

Домнина

Вольева

2021

Polymers for Advanced Techs

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Hybrid macromolecular antioxidants has evolved into a mature research field last three decades. The main concept of this area was to design polymer conjugates that combine in one structure the hydrophilic properties of a polymer backbone and biological efficiency of hydrophobic antioxidants. Over the years, the understanding of different aspects of such approach has grown. In general, meticulous selection of each component is essential to obtain the conjugate with required properties. This review overview a plethora of hybrid macromolecular antioxidants synthesized over the last 20 years, together with the discussion their physicochemical properties and application for biomedical purposes.

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