Aggression and Serotonin. Contribution of Inhibitory Mechanisms.

The serotonergic system participates in the modulation of aggressive behaviour. We examined the neuronal substrate underlying serotonergic control of aggressive behaviour in rats using a transplantation technique. Fetal serotonergic neurons transplanted into the hypothalamus restored inhibition of mouse-killing behaviour (muricide), in rats with raphe lesions induced by a serotonergic neurotoxin, 5,7-dihydroxytryptamine. Immunohistochemical and neurochemical studies indicated that the recovery of serotonergic innervation in the lateral hypothalamic area by the raphe grafts brought about the inhibition of muricide. The extension of serotonergic fibres into the lateral hypothalamic area from the grafted serotonergic neurons is strongly related to inhibition of muricide. These results indicate the possibility that serotonergic neurons regulate muricide through the inhibition of the activity of the lateral hypothalamic area neurons.

show abstract

Hypothalamic aggression area under serotonergic control in mouse-killing behaviour of rats

Ueda

Isizuya-Oka

Nishimura

et al. 1999

Int. J. Neuropsychopharm.

Self Cite

View full text Add to dashboard Cite

show abstract

Vimentin-Immunoreactivity in the Developing Striatum of the Rat.

Hagiwara

Eguchi

Ueda

1999

Acta Histochem. Cytochem

Self Cite

View full text Add to dashboard Cite

Induction of Fos-Like Immunoreactivity in the Lateral Hypothalamic Area of the Rat After Muricide

Ueda

Noda

2006

KANSEI Engineering International

Self Cite

View full text Add to dashboard Cite

Serotonergic innervation in the lateral hypothalamic area (LHA) has been implicated in mouse-killing behavior, muricide, of rats. In the present study, functional activation of neurons in the LHA was demonstrated by immunohistochemistry of Fos-protein, a marker of activated neurons, following raphe lesion-induced muricide. Fos-protein induction was seen in the ventral part of the intermediate hypothalamic area (IHA) of the LHA in the muricide rat. Following raphe transplantation into the brain near the bilateral IHA, a significant decrease in the number of Fos-immunoreactive cells was observed in this area, coinciding with decreased muricide behavior. The present results suggest that the decline in Fos-protein expression in this area may be associated with the inhibition of this behavior.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Aggression and Serotonin. Contribution of Inhibitory Mechanisms.

Abstract: Transplantationof fetal serotonergic neurons into the hypothalamus restored muricide

Cited by 3 publications

References 13 publications

Hypothalamic aggression area under serotonergic control in mouse-killing behaviour of rats

Hypothalamic aggression area under serotonergic control in mouse-killing behaviour of rats

Vimentin-Immunoreactivity in the Developing Striatum of the Rat.

Induction of Fos-Like Immunoreactivity in the Lateral Hypothalamic Area of the Rat After Muricide

Contact Info

Product

Resources

About