Aggression, hyperactivity and platelet imipramine binding

Marazziti, Donatella; Conti, L

doi:10.1111/j.1600-0447.1991.tb03130.x

“…29,32,63 The results are also consistent with investigations of various platelet markers of serotonin among other psychiatric disorders characterized by poor impulse control. 20,21,64,65 Similar to other reports, 30,66 cocaine patients in our study scored higher than controls on most measures of impulsivity, sensation seeking, and aggression. Furthermore, one behavioral measure of impulsivity, one of sensation seeking, and two of aggression combined to strongly predict low paroxetine Bmax among cocaine patients.…”

Section: Discussionsupporting

confidence: 88%

Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African-American Cocaine Abusers

Patkar¹,

Gottheil²,

Berrettini³

et al. 2003

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We investigated whether platelet-tritiated paroxetine binding, a measure of serotonin uptake sites, and behavioral measures of impulsivity, aggression, and craving differed between cocaine-dependent subjects and controls and whether paroxetine binding was related to these behavioral measures. One hundred and five African-American cocaine-dependent outpatients and 44 African-American controls were studied. Tritiated paroxetine binding sites on platelets were assayed, and standardized assessments of impulsivity, aggression, and craving were performed. The Bmax values of paroxetine binding were significantly reduced among cocaine patients compared to controls. Cocaine patients showed significantly higher scores on certain measures of sensation seeking, impulsivity, and aggression as compared to controls. Furthermore, paroxetine binding showed a significant negative correlation with most measures of sensation seeking, impulsivity, and aggression--though not craving--among cocaine patients. Our findings indicate that densities of serotonin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions.

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“…Most of these studies found that abnormalities of serotonin function were related to impulsivity‐aggression among cocaine abusers 29,32,63 . The results are also consistent with investigations of various platelet markers of serotonin among other psychiatric disorders characterized by poor impulse control 20,21,64,65 …”

Section: Discussionsupporting

confidence: 73%

Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African‐American Cocaine Abusers

Patkar

¹

,

Gottheil

²

,

Berrettini

³

et al. 2003

View full text Add to dashboard Cite

We investigated whether platelet-tritiated paroxetine binding, a measure of serotonin uptake sites, and behavioral measures of impulsivity, aggression, and craving differed between cocaine-dependent subjects and controls and whether paroxetine binding was related to these behavioral measures. One hundred and five African-American cocaine-dependent outpatients and 44 African-American controls were studied. Tritiated paroxetine binding sites on platelets were assayed, and standardized assessments of impulsivity, aggression, and craving were performed. The Bmax values of paroxetine binding were significantly reduced among cocaine patients compared to controls. Cocaine patients showed significantly higher scores on certain measures of sensation seeking, impulsivity, and aggression as compared to controls. Furthermore, paroxetine binding showed a significant negative correlation with most measures of sensation seeking, impulsivity, and aggression--though not craving--among cocaine patients. Our findings indicate that densities of serotonin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions.

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“…Serotonin receptor binding potential studies attempt to index serotonin receptor affinity or density by examining peripheral blood platelet binding (e.g., Coccaro, Kavoussi, Sheline, Lish, & Csernansky, 1996) or regional receptor density using positron emission tomography (Witte et al, 2009). Similar to other methods of assessing serotonin, binding potential studies have been characterized by inconsistent, contradictory, and null findings (e.g., Castrogiovanni, Capone, Maremmani, & Marazziti, 1994; Maguire et al, 1997; Marazziti & Conti, 1991). For example, the two published studies utilizing the high 5-HT 1A affinity radioligand [carbonyl-11C]WAY-100635 to measure the density of 5-HT 1A receptors in the prefrontal and anterior cingulate cortices and their relation to aggression found opposite results (Parsey et al, 2002; Witte et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Revisiting the serotonin–aggression relation in humans: A meta-analysis.

Duke¹,

Bègue²,

Bell³

et al. 2013

Psychological Bulletin

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The inverse relation between serotonin and human aggression is often portrayed as “reliable,” “strong,” and “well-established” despite decades of conflicting reports and widely recognized methodological limitations. In this systematic review and meta-analysis we evaluate the evidence for and against the serotonin deficiency hypothesis of human aggression across four methods of assessing serotonin: (a) cerebrospinal fluid levels of 5-hydroxyindoleacetic acid (CSF 5-HIAA), (b) acute tryptophan depletion, (c) pharmacological challenge, and (d) endocrine challenge. Results across 175 independent samples and over 6,500 total participants were heterogeneous, but, in aggregate, revealed a small, inverse correlation between central serotonin functioning and aggression, anger, and hostility, r = −.12. Pharmacological challenge studies had the largest mean weighted effect size, r = −.21, and CSF 5-HIAA studies had the smallest, r = −.06, p = .21. Potential methodological and demographic moderators largely failed to account for variability in study outcomes. Notable exceptions included year of publication (effect sizes tended to diminish with time) and self-versus other-reported aggression (other-reported aggression was positively correlated to serotonin functioning). We discuss four possible explanations for the pattern of findings: unreliable measures, ambient correlational noise, an unidentified higher-order interaction, and a selective serotonergic effect. Finally, we provide four recommendations for bringing much needed clarity to this important area of research: acknowledge contradictory findings and avoid selective reporting practices; focus on improving the reliability and validity of serotonin and aggression measures; test for interactions involving personality and/or environmental moderators; and revise the serotonin deficiency hypothesis to account for serotonin’s functional complexity.

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Aggression, hyperactivity and platelet imipramine binding

Cited by 16 publications

References 32 publications

Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African-American Cocaine Abusers

Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African-American Cocaine Abusers

Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African‐American Cocaine Abusers

Revisiting the serotonin–aggression relation in humans: A meta-analysis.

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