Aggression in Women with Schizophrenia Is Associated with Lower HDL Cholesterol Levels

Herceg, Dora; Mímica, Ninoslav; Herceg, Miroslav; Puljić, Krešimir

doi:10.3390/ijms231911858

Cited by 11 publications

(5 citation statements)

References 26 publications

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“…In [39]. Additionally, lower HDL levels have been associated with SCZ and psychosis in various studies [40][41][42]. Consistent with this, we observed negative genetic correlations between HDL and SCZ.…”

Section: Discussionsupporting

confidence: 90%

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Multi-trait genetic analysis identifies novel pleiotropic loci for depression and schizophrenia in East Asians

Song,

Li,

Jiang

et al. 2024

Preprint

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BackgroundWhile genetic correlations, pleiotropic loci, and shared genetic mechanisms of psychiatric disorders have been extensively studied in European populations, the investigation of these factors in East Asian populations has been relatively limited.MethodsTo identify novel pleiotropic risk loci for depression and schizophrenia (SCZ) in East Asians. We utilized the most comprehensive dataset available for East Asians and quantified the genetic overlap between depression, SCZ, and their related traits via a multi-trait genome-wide association study. Global and local genetic correlations were estimated by LDSC and ρ-HESS. Pleiotropic loci were identified by the MTAG.ResultsBesides the significant correlation between depression and SCZ, our analysis revealed genetic correlations between depression and obesity-related traits, such as weight, BMI, T2D, and HDL. In SCZ, significant correlations were detected with HDL, heart diseases and use of various medications. Conventional meta-analysis of depression and SCZ identified a novel locus at 1q25.2 in East Asians. Further multi-trait analysis of depression, SCZ and related traits identified ten novel pleiotropic loci for depression, and four for SCZ.ConclusionsOur findings demonstrate shared genetic underpinnings between depression and SCZ in East Asians, as well as their associated traits, providing novel candidate genes for the identification and prioritization of therapeutic targets specific to this population.

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Section: Discussionsupporting

confidence: 90%

“…Notably, Liang et al reported that low HDL levels may be linked to more severe depressive symptoms in East Asian populations [39]. Additionally, lower HDL levels have been associated with SCZ and psychosis in various studies [40–42]. Consistent with this, we observed negative genetic correlations between HDL and SCZ.…”

Section: Discussionsupporting

confidence: 89%

Multi-trait genetic analysis identifies novel pleiotropic loci for depression and schizophrenia in East Asians

Song,

Li,

Jiang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Herceg et al pointed out that in female schizophrenia patients, lowered HDL cholesterol levels have been associated with aggression. 25 Another study showed that higher prolactin was significantly associated with aggression in female schizophrenia patients. 26 Persons with schizophrenia frequently experience depressive mood, and a meta-analysis including 9879 persons with schizophrenia indicated that the frequency of co-morbid depression in schizophrenia was about 28.6%.…”

Section: Discussionmentioning

confidence: 99%

An Exploration of Depression and Aggression Among Patients with Schizophrenia in China Rural Community

Zhang,

Ouyang,

Yang

et al. 2024

PRBM

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Purpose In schizophrenia, aggressive conduct is frequent. And depressed mood can also contribute to the occurrence of aggressive behaviors. The aim of this study was to investigate the risk factors for the occurrence of aggression in stable schizophrenia patients in rural China, mainly to investigate the role of depressed mood in the occurrence of aggression in schizophrenia patients. Patients and Methods This is a cross-sectional study conducted in the townships surrounding Chaohu City, Anhui Province, China. Patients’ depressive mood was evaluated using the PHQ-9 (The 9-item Patient Health Questionnaire). Patients’ aggressiveness was evaluated using the Modified Overt Aggression Scale (MOAS). A score of ≥4 was used as a threshold and divided into aggressive and non-aggressive groups. Results This study comprised a total of 821 schizophrenia patients. Among them, the prevalence of having aggressive behavior was 18.8%. After correcting for confounders, logistic regression analysis showed that low education level (OR=0.470, 95% CI 0.254–0.870; p=0.016), living with family (OR=0.383, 95% CI 0.174–0.845; p=0.017) depressed mood (OR=1.147, 95% CI 1.112–1.184; p<0.001) was significantly associated with the risk of aggressive behavior in patients with schizophrenia. Multivariate linear regression indicated that higher levels of aggression were linked with lower levels of education and higher depressive mood. Conclusion This study suggests that aggression is more common in patients with stable schizophrenia, and lower levels of education and higher levels of depression are associated risk factors for its occurrence. Living alone may be helpful in reducing the likelihood of aggression.

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“…Simultaneously, research has highlighted that lipoprotein metabolism’s role extends beyond the metabolic side effects in schizophrenia to include the disorder’s psychiatric symptoms. For instance, a study identified a strong link between low HDL serum levels and increased aggression in female schizophrenia patients ( Herceg et al, 2022 ). In contrast, another study observed that rising serum HDL levels during the first year of antipsychotic treatment corresponded with reduced negative symptoms ( Gjerde et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects

Huang,

Sun,

Luo

et al. 2024

Front. Pharmacol.

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Schizophrenia significantly impacts cognitive and behavioral functions and is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which can diminish patient compliance, worsen psychiatric symptoms and increase cardiovascular disease risk. This study explores the hypothesis that SGAs affect the molecular determinants of synaptic plasticity and brain activity, particularly focusing on the lateral septum (LS) and its interactions within hypothalamic circuits that regulate feeding and energy expenditure. Utilizing functional ultrasound imaging, RNA sequencing, and weighted gene co-expression network analysis, we identified significant alterations in the functional connection between the hypothalamus and LS, along with changes in gene expression in the LS of mice following prolonged olanzapine exposure. Our analysis revealed a module closely linked to increases in body weight and adiposity, featuring genes primarily involved in lipid metabolism pathways, notably Apoa1, Apoc3, and Apoh. These findings suggest that olanzapine may influence body weight and adiposity through its impact on lipid metabolism-related genes in the LS. Therefore, the neural circuits connecting the LS and LH, along with the accompanying alterations in lipid metabolism, are likely crucial factors contributing to the weight gain and metabolic side effects associated with olanzapine treatment.

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Aggression in Women with Schizophrenia Is Associated with Lower HDL Cholesterol Levels

Cited by 11 publications

References 26 publications

Multi-trait genetic analysis identifies novel pleiotropic loci for depression and schizophrenia in East Asians

Multi-trait genetic analysis identifies novel pleiotropic loci for depression and schizophrenia in East Asians

An Exploration of Depression and Aggression Among Patients with Schizophrenia in China Rural Community

Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects

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