Aggressive Angiomyxoma of the Vulva: A Précis for Primary Care Providers

Abstract

Vulvar aggressive angiomyxoma (AA) is a rare mesenchymal tumor of the vulva. Due to its slow-growing nature, it is often overlooked and misdiagnosed by primary care providers (PCPs). We describe a case report of vulvar AA in a 38-year-old woman who underwent complete surgical excision of the neoplasm with no evidence of recurrence on a 5-year followup. A literature review follows to provide PCPs with the clinical, radiologic, and pathologic features that this tumor displays.

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“…Treatment with GnRH agonists has been successful in some cases where the tumor was PR and ER positive [8,39,40]. GnRH agonists can also be used preoperatively to shrink tumors and increase the chance for complete excision [41]. AA has a high rate of local recurrence [42].…”

Aggressive angiomyxoma of the vulva: case report

“…The pathogenesis of vulvar AA is poorly extended, however, genetic changes in short arm of the chromosome 12(12q) has been implicated as the cause. ( 6 ) The histopathology exam is the gold standard diagnosis and, often, shows vessels of medium size and thickness wall, rounded by layer of stromal cells of myxoid appearance. ( 4 ) Histologically this tumor is hypo-or moderately cellular being fusiform or stellar cells in between the myxoid matrix of mucopolysaccharides, involving a number of vessels of small and medium size – being this latter, sometimes, of thickness and hyalinized wall.…”

Aggressive Angiomixoma of the Vulva: Case Report

“…7 Mitotic figures and nuclear atypia are almost always absent. 8 In this case, microscopic view and staining properties were found similar to the literature data.…”