Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: A case report and review of the literature

Sperti, Cosimo; Berselli, Mattia; Pasquali, Claudio; Pastorelli, Davide; Pedrazzoli, Sergio

doi:10.3748/wjg.14.960

Cited by 92 publications

(97 citation statements)

References 35 publications

(103 reference statements)

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“…Although SPTP is considered to be an indolent lesion with a low malignant potential and a favorable prognosis following surgical resection, a number of cases of locally infiltrating and metastatic varieties and post-surgical recurrences have been reported (19).…”

Section: Discussionmentioning

confidence: 99%

Pathology comparative study on the characteristic CT signs in solid pseudopapillary neoplasm of the pancreas

Hao

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. In order to analyze characteristic CT signs in the solid pseudopapillary tumor of the pancreas, a retrospective analysis was conducted on 49 patients with pseudopapillary tumor of the pancreas who where treated in Liaoning Cancer Hospital. All of the patients were confirmed by pathology, CT signs were analyzed and a pathology contrast was conducted. Furthermore, all cases had single lesions; 7 cases in the pancreatic head, 23 cases in the pancreatic body, 15 cases in the pancreatic body-tail and 4 cases in the pancreatic tail. The boundaries of the lesions were clear and the tumors, which may outline the pancreas, were composed of solid and polycystic parts. In addition, calcifications could be observed in the lesions and CT results revealed varying degrees of contrast enhancement of the solid components in the arterial phase, as well as a gradual contrast enhancement in the venous and delayed phase. Enhancement of capsule could be observed, and the enhancement region was observed in the solid part, no enhancement in cystic part.. In conclusion, CT manifestations of solid pseudopapillary tumors of the pancreas are specific, which is helpful to the diagnosis. IntroductionSolid pseudopapillary tumor of the pancreas (SPTP) is a rare tumor that is benign or low-grade malignant, with benign or malignant potential, and a low incidence rate, accounting for 0.2-2.7% of the total pancreatic tumors (1). Since it has no characteristic clinical manifestations and a low incidence rate, the preoperative diagnosis rate is low. Furthermore, the treatment principle is different from other pancreatic tumors and an improvement of the preoperative diagnosis rate is important.SPTP is known to occur preferentially in young females and has a favorable prognosis (2-4). The characteristic imaging features of SPTPs include encapsulation, solid and cystic components and peripheral calcification (5-7). Furthermore, there exists no consensus on a common location of the tumor within the pancreas and they usually affect young women at an average age of 28 years old with a female:male ratio of 10:1 (8). However, sporadic rare cases in males and in the elderly have been reported. The tumor has a low-grade malignant potential and tends to have a favorable prognosis following resection, even in the presence of metastatic disease of up to 20% of cases (8). The overall 5-year survival exceeds 90%, including patients with metastatic disease (9). Males, elderly, histopathologically atypical tumors and incomplete resections have been associated with a higher risk of recurrence and mortality (9).To date, enhanced computed tomography (CT) has become a common examination method for pancreatic diseases, and understanding the enhanced characteristic CT signs of SPTP has important clinical significance. Therefore, the present study summarized the CT signs of 49 cases who received surgery in Liaoning Cancer Hospital (Shenyang, China) between January 2002 and May 2014, and then compared these with the pathological examination. Materials and methodsC...

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Section: Discussionmentioning

confidence: 99%

Pathology comparative study on the characteristic CT signs in solid pseudopapillary neoplasm of the pancreas

Hao

et al. 2017

Experimental and Therapeutic Medicine

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“…The reported incidence of SPN is extremely low, accounting for only 0.17-2.7% of all exocrine pancreatic tumors (1). In addition, only 10% of reported SPN patients are men (2). Most SPNs occur in the body or tail of the pancreas and form large tumors (average size, 10 cm) (8).…”

Section: Discussionmentioning

confidence: 99%

“…Most SPN patients are women; less than 10% of reported SPN patients in the literature are men (2). SPN is usually detected as a heterogeneous mass with a combination of solid and cystic areas, with larger tumors containing areas of calcification in the tumor wall.…”

Section: Introductionmentioning

confidence: 99%

Solid Pseudopapillary Neoplasm of the Pancreas Associated with Familial Adenomatous Polyposis

et al. 2015

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A man in his thirties visited our hospital for an evaluation of a 12×10-mm pancreatic solid tumor that was accidentally detected on computed tomography performed for follow-up of familial adenomatous polyposis (FAP). We diagnosed the patient with a solid pseudopapillary neoplasm (SPN) based on endoscopic ultrasound-guided fine-needle aspiration, and he underwent pancreaticoduodenectomy. Small SPN tumors appear as solid tumors, without typical features of SPN, making the definitive diagnosis more difficult. The genetic background of FAP patients can predispose them to SPN, and imaging of the pancreas should be performed at prescribed intervals in FAP patients.

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“…At 4 months of follow-up, the patient had no evidence of residual tumor or tumor recurrence. The case of an SPN with venous invasion, moderate cellular atypia, and mitotic activity was described in a 49-year-old woman by Sperti et al 6 At 32 months of follow-up, the patient was found to have multiple metastatic lesions throughout the liver. The patient underwent numerous chemotherapeutic regimens and was asymptomatic with stable disease on imaging at 45 months post recurrence.…”

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confidence: 99%

“…[1][2][3][4] Solid pseudopapillary neoplasms are being recognized with increasing frequency owing to increasingly widespread use of imaging techniques, along with a better knowledge and understanding of the disease. 5,6 The first report of an SPN of the pancreas was described in a 19-year-old woman by Dr Frantz in 1959. 1 At that time he called this neoplasm a ''papillary tumor of the pancreas, benign or malignant.''…”

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confidence: 99%

Aggressive Variant of a Solid Pseudopapillary Neoplasm: A Case Report and Literature Review

Reindl

Lynch

Jassim

2014

Archives of Pathology &Amp; Laboratory Medicine

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Solid pseudopapillary neoplasm, a lesion of uncertain cellular differentiation, is an unusual tumor of the pancreas with an indolent clinical course that typically arises in young females. We report a case of solid pseudopapillary neoplasm arising in a 17-year-old adolescent girl who presented with progressive abdominal pain. The patient underwent surgical resection of an 18 × 14 × 8-cm pancreatic mass that displayed the usual histologic features of a solid pseudopapillary neoplasm in addition to prominent nuclear atypia, increased proliferative index, and extensive necrosis. These unusual histologic findings are rare and are of particular interest owing to the dramatically decreased survival time displayed in this case. Although precise pathologic criteria suggesting a high risk for aggressive behavior of solid pseudopapillary neoplasms are uncertain, recognition of the unusual pathologic features displayed in this case may be useful in the prediction of potentially more aggressive neoplasms that portend a poorer prognosis.

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Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: A case report and review of the literature

Cited by 92 publications

References 35 publications

Pathology comparative study on the characteristic CT signs in solid pseudopapillary neoplasm of the pancreas

Pathology comparative study on the characteristic CT signs in solid pseudopapillary neoplasm of the pancreas

Solid Pseudopapillary Neoplasm of the Pancreas Associated with Familial Adenomatous Polyposis

Aggressive Variant of a Solid Pseudopapillary Neoplasm: A Case Report and Literature Review

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