Aggressive digital papillary adenocarcinoma of the hand: An unsuspected malignant tumour of the sweat glands

Villén, Gregorio Martínez; Alegret, Ramiro Álvarez; Canales, V.; Herrera, Antonio

doi:10.3109/2000656x.2011.588452

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Diagnosis is difficult and always made after biopsy. ADPA often presents as a solitary, slow-growing lesion that can appear unchanged for years, then enlarges over a relatively short period 2 . Traumatic or chronic wound is a feature of some of the reported cases.…”

Section: Discussionmentioning

confidence: 99%

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An Aggressive Digital Papillary Adenocarcinoma and a Grossly Similar, Contralateral Callus

Miller

Guillen

Chen

et al. 2021

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Case: This is a case of a 44-year-old man with 10 years of history of painful callus-like swellings of bilateral index fingers. Sudden enlargement of the left index finger prompted biopsy, which revealed aggressive digital papillary adenocarcinoma (ADPA) that was treated with partial amputation. Biopsy of the contralateral finger revealed acanthotic skin with no evidence of malignancy. Conclusion: Several case reports cite antecedent insult and chronic swelling before diagnosis. We describe a case of bilateral lesions with similar gross appearances, a long history of occupational repetitive trauma, and sudden enlargement of 1 lesion leading to the diagnosis of ADPA.

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Section: Discussionmentioning

confidence: 99%

“…Aggressive digital papillary adenocarcinoma (ADPA) is a rare eccrine sweat gland malignancy with an affinity for the distal phalanx 1,2 . It was originally described by Helwig in 1984 as the malignant counterpart to aggressive digital papillary adenoma 3 .…”

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confidence: 99%

An Aggressive Digital Papillary Adenocarcinoma and a Grossly Similar, Contralateral Callus

Miller

Guillen

Chen

et al. 2021

JBJS Case Connector

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“…In a review of the literature, there have been few cases of primary sweat gland carcinoma of the hand from 1960 to 2012, 6 , 7 with the most recent descriptions being aggressive digital papillary adenocarcinomas in 2007 and 2012. 8 , 9 …”

Section: Discussionmentioning

confidence: 99%

Metastatic Invasive Sweat Gland Adenocarcinoma of the Hand with Upper Limb Amputation/Shoulder Reconstruction

Ramdass

Capildeo

2015

Plastic and Reconstructive Surgery - Global Open

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Summary:A rare case of metastatic invasive sweat gland adenocarcinoma of hand in a 78-year-old woman is presented. From this analysis of the available literature, it seems that these rare primary tumors of the hand are aggressive tumors with little known about their biological behavior. Fluoropyrimidines, taxanes, and cisplatin have been reported to be active agents for metastatic sweat gland carcinomas. Further, these tumors have historically been considered radioresistant, but responses to radiation have been documented in the setting of recurrent disease, and the use of adjuvant radiotherapy has been advocated for tumors at high risk of local recurrence. We advocate an aggressive approach of high amputation and axillary lymph node dissection with adjuvant treatment using chemotherapy as the mainstay with close follow-up for metastases.

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“…As the name suggests, this tumor usually occurs on fingers and toes with the most distal volar portion of the finger being the most common location. Non‐digital locations such as dorsum of hand, dorsum of foot, web spaces of fingers and toes, periungual/subungual, palm, sole and ankle have been described but very rare. Three largest series of this tumor reported so far do not have any case on the ankle .…”

mentioning

confidence: 99%

Papillary adnexal neoplasm (aggressive digital papillary adenocarcinoma) on the ankle of a 15‐year‐old girl: case report and review of literature from a pediatric perspective

Pimpalwar

Diwan

et al. 2016

J Cutan Pathol

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Digital papillary adenocarcinoma is a rare malignant tumor of the sweat glands, most commonly encountered in adult males. Only few pediatric cases have been reported, with an apparent predominance of females and none on the ankle. We report a case of a 15-year-old girl with a slowly growing, non-tender mass on the right ankle presenting with difficulty in walking; clinically believed to be a keloid. Excision of the mass revealed a glandular neoplasm with largely eccrine and focally apocrine differentiation. Histologic features do not reliably predict biologic behavior. Because of the existing confusion over the nomenclature, we propose that such tumors be called 'papillary adnexal neoplasms of distal extremities'.

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Aggressive digital papillary adenocarcinoma of the hand: An unsuspected malignant tumour of the sweat glands

Cited by 5 publications

References 6 publications

An Aggressive Digital Papillary Adenocarcinoma and a Grossly Similar, Contralateral Callus

An Aggressive Digital Papillary Adenocarcinoma and a Grossly Similar, Contralateral Callus

Metastatic Invasive Sweat Gland Adenocarcinoma of the Hand with Upper Limb Amputation/Shoulder Reconstruction

Papillary adnexal neoplasm (aggressive digital papillary adenocarcinoma) on the ankle of a 15‐year‐old girl: case report and review of literature from a pediatric perspective

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