Aggressive dissemination of central nervous system hemangioblastoma without association with von Hippel–Lindau disease: A case report and literature review

Abstract

Background: Hemangioblastomas (HBs) typically present with benign behavior and are most commonly found in the posterior fossa. Multiple central nervous system (CNS) HBs are usually associated with von Hippel–Lindau disease, and leptomeningeal dissemination of sporadic HBs is extremely rare. A review of the literature identified 30 cases of leptomeningeal dissemination of sporadic HBs previously published in the literature. Case Description: We report the case of a patient who was diagnosed with multiple CNS HBs with aggressive progression 6 years after resection of a posterior fossa HB. He underwent multiple surgeries and died 4 years after the diagnosis of the first spinal dissemination. Conclusion: Dissemination of sporadic HBs is rare and aggressive disease evolution is usually observed. Further studies are necessary to determine the optimal therapeutic options.

Patients With Hemangioblastoma: Mood Disorders and Sleep Quality

“…Further studies also acknowledge that primary and recurrent brain tumors often coincide with psychiatric and behavioral manifestations, including cognitive changes, personality shifts, perceptual disturbances, disruptions in thought content and processing, anxiety, agitation, and mood variations. The severity of these changes tends to correlate with the rapidity of tumor growth [ 10 11 ].…”