Aggressive granulomatous lesions associated with hip arthroplasty. Immunopathological studies.

Santavirta, Seppo; Yt, Konttinen; Bergroth, Ville; Eskola, Antti; Tallroth, Kaj; Ts, Lindholm

doi:10.2106/00004623-199072020-00014

Cited by 305 publications

(133 citation statements)

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“…Thus, the prosthetic interface provides a complex series of interactions of cells, cytokines and other substances which modulate bone remodelling. With cemented implants, differences were also found in the T-lymphocyte subgroups, suggesting a possible role for immunological processes in osteolysis, but this is con- troversial and there are studies which advocate 21,32,[43][44][45][46][47][48] and refute [49][50][51][52][53][54] a role for T-cell modulation of the macrophage response to biomaterials. 55,56 With cementless prostheses there were fewer differences in cell number and cytokine profile in the various groups.…”

Section: Discussionmentioning

confidence: 99%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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T he tissues surrounding 65 cemented and 36 cementless total joint replacements undergoing revision were characterised for cell types by immunohistochemistry and for cytokine expression by in situ hybridisation.We identified three distinct groups of revised implants: loose implants with ballooning radiological osteolysis, loose implants without osteolysis, and well-fixed implants. In the cemented series, osteolysis was associated with increased numbers of macrophages (

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Section: Discussionmentioning

confidence: 99%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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“…An interface membrane develops around the loosened prosthesis with a pseudosynovial layer adjacent to it. 1 Macrophages are predominant and epipolarised microscopy has shown that many are laden with wear particles. 2 The resultant cortical bone loss is considered to be caused by activation and release of a cascade of cell mediators by the pseudosynovial macrophages and other cells capable of phagocytosis of the prosthetic particulate debris.…”

Section: From the Royal Postgraduate Medical School London Englandmentioning

confidence: 99%

Aseptic Loosening Of Total Hip Replacement: Macrophage Expression Of Inducible Nitric Oxide Synthase And Cyclo-oxygenase-2, Together With Peroxynitrite Formation, As A Possible Mechanism For Early Prosthesis Failure

Hukkanen¹,

Corbett²,

Batten³

et al. 1997

The Journal of Bone and Joint Surgery

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Aseptic loosening is a major cause of failure of total hip arthroplasty. The adverse tissue response to prosthetic wear particles, with activation of cytokine and prostanoid production, contributes to bone loss around the implants. We have investigated the possibility that inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) are expressed in macrophages in the pseudomembrane at the bone-implant interface, thereby contributing to the periprosthetic bone resorption.We also assessed whether peroxynitrite, a nitric oxide (NO)-derived oxidant associated with cellular injury, is generated in the membrane. Enzymatic activity of iNOS was measured using the arginine-citrulline assay technique and prostaglandin E 2 (PGE 2 ), as an indicator of COX-2 activity, was measured using an enzyme immunoassay.Cellular immunoreactivity for iNOS, nitrotyrosine (a marker of peroxynitrite-induced cellular injury) and COX-2 was assessed by quantitative peroxidase immunocytochemistry while immunofluorescence methods were used for subsequent co-localisation studies with CD68 + macrophages.

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“…In the hip, wear of the polyethylene has been accepted as the most prominent drawback, with subsequent generation of debris, osteolysis, and aseptic loosening of the implant (Santavirta et al 1990, Willert et al 1990) related to submicron particles (McKellop et al 1995, Sabokbar et al 2003, Goodman 2005, Konttinen et al 2005) from different polyethylenes (Galvin et al 2007). The main issues in the knee are not wear-related, but include material fatigue, delamination, and fracture-particularly in component designs in which there is thin material in some regions.…”

mentioning

confidence: 99%