2010
DOI: 10.1186/1471-2407-10-540
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Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

Abstract: BackgroundActivation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an important regulator of genes induced by oxidative stress, such as glutathione S-transferases, heme oxygenase-1 and peroxiredoxin 1, by activating the antioxidant response element (ARE). We hypothesized that (1) the citrus coumarin auraptene may suppress premalignant mammary lesions via activation of Nrf… Show more

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Cited by 65 publications
(30 citation statements)
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“…These results as well as the results of the present study indicate that NRF2 plays an important role in the increased proliferative activity of breast carcinoma cells. On the other hand, previous reports had also indicated the protective role of NRF2 against DNA damage and mammary carcinogenesis in non-neoplastic breast epithelial cells (Singh & Bhat 2012, Singh et al 2013, and Becks et al (2010) reported that Nrf2-knockout mice were more susceptible to mammary carcinogenesis. Therefore, NRF2 may have dual roles in breast carcinoma, i.e.…”
Section: Discussionmentioning
confidence: 96%
“…These results as well as the results of the present study indicate that NRF2 plays an important role in the increased proliferative activity of breast carcinoma cells. On the other hand, previous reports had also indicated the protective role of NRF2 against DNA damage and mammary carcinogenesis in non-neoplastic breast epithelial cells (Singh & Bhat 2012, Singh et al 2013, and Becks et al (2010) reported that Nrf2-knockout mice were more susceptible to mammary carcinogenesis. Therefore, NRF2 may have dual roles in breast carcinoma, i.e.…”
Section: Discussionmentioning
confidence: 96%
“…Our findings suggest that BTG2 may also serve such a function. Interestingly, NFE2L2 has been identified as a potential target for cancer prevention, based on studies showing that: 1) NFE2L2 knock-out mice are more sensitive to colitis-induced colon cancer and carcinogeninduced mammary cancer (41,42); and 2) various proposed cancer prevention agents (e.g. diindolylmethane and sulforaphane) stimulate NFE2L2 signaling (29,(43)(44)(45)).…”
Section: Discussionmentioning
confidence: 99%
“…Treatment with 7,12-dimethylbenz(a)anthracene and medroxyprogesterone acetate induced premalignant lesions and mammary carcinomas in mice. Although no apparent difference in the formation of the premalignant lesions was observed between Nrf2 knockout and wild-type mice, the knockout mice exhibited rapid and aggressive mammary carcinoma progression (Becks et al, 2010).…”
Section: A Carcinogenesismentioning
confidence: 99%