“…Currently, the main prognostic factors for MCL patients include age, MIPI, histology, TP53 aberrations and tumor proliferation. When comparing cases with blastoid/pleomorphic vs. classic morphology and high vs. low proliferation rate measured by Ki-67 expression, we observed that TP53 and ATM were the most frequently altered genes in aggressive morphologic variants, being mutually exclusive, which has been shown previously [20]. FAT4, CCND1, SAMHD1, UBR,5 and FAT3 genes were mutated only in nonaggressive cases, i.e.…”