Aggressive osteoblastoma of the mandible

Lypka, Michael; Goos, R.R.; Yamashita, Dennis-Duke; Melrose, Raymond J.

doi:10.1016/j.ijom.2008.01.013

Cited by 34 publications

(31 citation statements)

References 11 publications

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“…In addition, they reported that these tumours were characterized by the presence of epitheloid osteoblasts. Lypka et al 24 reported a large mixed lesion in the mandible. As an expansile lesion contained larger spaces filled with sheets of epitheloid osteoblasts, it was diagnosed as aggressive osteoblastoma.…”

Section: Discussionmentioning

confidence: 98%

Recurrent osteoblastoma of the maxilla

Shah¹,

Kim²,

Kh³

et al. 2013

Dentomaxillofacial Radiology

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Osteoblastoma is a benign neoplasm which commonly occurs in the vertebral column and long bones. The tumour grows slowly and rarely recurs after surgery. This report presents the clinicopathological and radiological findings of a case of recurrent osteoblastoma in the maxilla. A 7-year-old male patient visited our department with chief complaints of left facial swelling and pain. A panoramic radiograph showed a homogeneous radio-opaque expansile lesion in the left maxilla. The lesion was thought to be fibrous dysplasia and the patient underwent a surgical excision using the Caldwell-Luc procedure. Histopathological examination of the lesion confirmed it as benign osteoblastoma. The lesion recurred 6 months after the initial surgery. CT images revealed a large mass with multiple internal calcifications. Subsequently, the patient underwent mass excision with subtotal left maxillectomy. Follow-up CT scans at 1 year intervals showed no recurrence for 5 years. Dentomaxillofacial Radiology ( Keywords: osteoblastoma; recurrence; X-ray computed tomography Case reportA 7-year-old male patient visited our department with the chief complaints of left facial swelling and pain. His medical history was unremarkable. Clinical and radiographic examinations were performed. Intraoral examination revealed a firm gingivobuccal swelling extending from the left maxillary deciduous lateral incisor to the left maxillary permanent first molar. Panoramic radiographs showed a homogeneous radio-opaque expansile lesion in the left maxilla and the lesion involved the whole maxilla. The adjacent tooth germs were displaced and the innominate line in the left maxillary sinus was not detected (Figure 1). The lesion was thought to be fibrous dysplasia from the initial clinical and panoramic radiographic findings; therefore, mass excision using the Caldwell-Luc operation was performed. The surgical specimen was 3.5 cm in diameter and it was spherical, encapsulated and firm tissue. On histopathological examination, bony trabeculae surrounded by a single layer of plump osteoblasts of high cellularity were observed in the stroma. There was no atypia or mitotic activity in the osteoblasts or in the mesenchymal cells of the stroma. Most of the calcifications consisted of woven bone without obvious lamellation. Multinuclear giant cells were often identified around the osteoid. As the trabeculation progressed, the stroma changed into loose fibrovascular tissue. The lesion was finally diagnosed as benign osteoblastoma (Figure 2).The patient revisited our department with an enlarged swelling in the same region 6 months after the operation. CT images revealed a large well-defined mass composed of two locules with multiple internal calcifications. Owing to the expansive nature of the lesion, the left orbital floor was elevated and the lateral wall of the left nasal cavity was pushed towards the medial side (Figure 3). The patient had undergone mass excision with subtotal left maxillectomy. The surgical specimens were composed of two, solid, firm soft-tissue ...

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Section: Discussionmentioning

confidence: 98%

Recurrent osteoblastoma of the maxilla

Shah¹,

Kim²,

Kh³

et al. 2013

Dentomaxillofacial Radiology

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“…This benign bone-forming neoplasm typically affects patients between the ages of 10-30 years and is most commonly found in the vertebral column and long bones [5,6]. When present in the head and neck, the most common site of involvement is the gnathic skeleton with the mandible being affected 2-3 times more frequently than the maxilla.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the aggressive behavior and propensity for recurrence associated with EO, the recommended treatment for these lesions is surgical resection with wide margins and subsequent reconstruction. Adjuvant radiation and/or chemotherapy are contraindicated [1,2,4,5]. The patient in this case underwent resection of the lesion and currently has an oral-antral fistula.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid Osteoblastoma

Britt

Murphey

Castle

2012

Head and Neck Pathol

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“…Histologically, the appearance can be variable with bony trabeculae in a loose fibrovascular stroma, plasmacytoid to large epithelioid osteoblasts with vesicular nuclei containing eosinophillic cytoplasm, prominent osteoid production with osteoblastic rimming, and minimal mitotic activity [4,6]. At times, atypical cells that are large, multinucleate, with unusual degenerative nuclear features, and prominent nucleoli can be seen [8,9]; thus, differentiating this lesion from OS can be difficult. In fact, one histological variant, with multiple nidi of epithelioid osteoblasts, a pattern difficult to discern from OS, has a predilection for the jaws [10].…”

Section: Discussionmentioning

confidence: 99%

“…Differentiating OB from OS can be extremely challenging given that the former can display locally aggressive behavior that is not histopathologically predictable. Aggressive OB may have more epithelioid osteoblasts, increased mitotic activity, and more contiguous areas of osteoid; the question has been raised whether aggressive OB is a distinct clinicopathologic entity [9]. Features that distinguish OS from OB include poor circumscription with infiltration of normal bone by the neoplastic cells, nuclear pleomorphism, and increased mitotic activity with abnormal figures (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Case Report: a Pediatric Case of Cementoblastoma with Histologic and Radiographic Features of an Osteoblastoma and Osteosarcoma

Bilodeau

Collins

Costello

et al. 2010

Head and Neck Pathol

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One case of an expansile mass involving the roots of a mandibular left first molar in a nine year old male is presented. The lesion has features of a cementoblastoma (CB), osteoblastoma (OB), and osteosarcoma (OS) both radiographically and histologically. Radiographically, a ''sunburst'' appearance is present. Histologically, the lesional tissue is intimately involved with the root, not the periosteum. The clinical, radiographic, and histopathologic characteristics of CB, OB, and OS are discussed as well as the difficulties associated with distinguishing between these lesions in the gnathic region.

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Aggressive osteoblastoma of the mandible

Cited by 34 publications

References 11 publications

Recurrent osteoblastoma of the maxilla

Recurrent osteoblastoma of the maxilla

Epithelioid Osteoblastoma

Case Report: a Pediatric Case of Cementoblastoma with Histologic and Radiographic Features of an Osteoblastoma and Osteosarcoma

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