Aggressive Pilomatricoma in Childhood

Inglefield, Christopher; Muir, I.F.K.; Gray, E. S.

doi:10.1097/00000637-199412000-00018

Cited by 16 publications

(9 citation statements)

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“…3,4,[6][7][8]10,11,13,16,17,21,24,25,27,29 The main differential includes proliferating pilomatrixoma, aggressive pilomatrixoma, and basal cell carcinoma with matrical differentiation (Table 2). [33][34][35] Although pilomatrix carcinoma is morphologically similar to an aggressive pilomatrixoma, it contains greater nuclear pleomorphism, frequent and atypical mitoses, and perineural and vascular invasion. 2,7,21,32 They differ from pilomatrix carcinomas, as they are symmetric well-circumscribed neoplasms with an expansile growth pattern.…”

Section: Discussionmentioning

confidence: 99%

Pilomatrix Carcinoma

Cornejo

Deng

2013

The American Journal of Dermatopathology

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Pilomatrixoma is a common benign neoplasm of children and young adults with a female predilection. In contrast, its malignant counterpart, pilomatrix carcinoma is a rare neoplasm of older adults with a male preponderance. Pilomatrix carcinomas are locally aggressive with a tendency to recur. We report a case of a 44-year-old male who presented with an enlarging soft tissue tumor on the right upper back. Histology revealed an asymmetric, poorly circumscribed, lobulated neoplasm located deeply in the dermis with infiltration into the underlying subcutaneous tissue. The tumor was comprised of basaloid cells containing vesicular nuclei, prominent nucleoli, scant cytoplasm, and brisk mitotic activity. A focus of basaloid cells transitioning to shadow cells with central keratinized material and tumor necrosis was also present. The diagnosis of a pilomatrix carcinoma was rendered. Considering the infiltrative nature of this neoplasm with perineural and intramuscular invasion, the patient underwent 3 surgical excisions before it was completely removed.

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Section: Discussionmentioning

confidence: 99%

Pilomatrix Carcinoma

Cornejo

Deng

2013

The American Journal of Dermatopathology

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“…The shadow squamous cells and basaloid cells are surrounded by background of inflammatory cells and fragments of calcified material. According to Inglefield et al, 6 aggressive PMX in addition to the presence of excessive basaloid cell proliferation shows discrete nodules distant from main lesion and a high mitotic rate. It has the ability to infiltrate the surrounding tissues and a capacity to recur.…”

Section: Discussionmentioning

confidence: 99%

“…The key histologic features of aggressive PMX are a high mitotic rate and presence of excessive basaloid proliferation with discrete nodules distant from main lesion. 5,6 We review a case of aggressive PMX, misdiagnosed as small round cell tumor on fine-needle aspiration cytology. We discuss this case because of its potential diagnostic pitfall on cytology, distinctive histomorphological features, and a tendency for recurrence.…”

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Pilomatrixoma: A Diagnostic Pitfall in Fine Needle Aspiration Cytology

Gupta¹,

Gupta²,

Kumar³

et al. 2014

jemds

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We report a case of aggressive pilomatrixoma (PMX) in a 25-year-old male who presented with swelling in left supraclavicular region of 2-month duration. A diagnosis of small round cell tumor was suggested on fine-needle aspiration cytology. He underwent wide excision of the mass. On histomorphological examination, a diagnosis of aggressive PMX was made. The swelling recurred after 3 months of complete resection and on examination had similar morphological features. The case is presented because of the potential diagnostic difficulties on cytological examination and rare occurrence of aggressive variant of PMX. Diagn. Cytopathol. 2014;42:906-911. V C 2014 Wiley Periodicals, Inc.

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“…The infiltrative growth pattern, the high mitotic rate and the presence of excessive basaloid cell proliferation characterize the aggressive type of pilomatrixoma, which may be histologically difficult to differentiate from basal cell carcinoma, proliferating pilar cyst and pilomatrix carcinoma [18]. It has the ability to locally invade adjacent structures and has the capacity to recur [19].…”

Section: Discussionmentioning

confidence: 99%

A patient with ulcerated calcifying epithelioma of Malherbe in the pinna: case report

et al. 2012

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IntroductionAlthough pilomatrixomas are frequently encountered by dermatologists and pathologists in the differential diagnosis of head and neck lesions, this is not usually the case among head and neck surgeons.A pilomatrixoma (calcifying epithelioma of Malherbe) is a benign tumour of the hair matrix cells. Histologically it is characterised by the presence of ghost cells, basophilic cells and foreign body cells. It may sometimes be difficult to histologically distinguish it from its malignant counterpart, the pilomatrix carcinoma.We report an interesting case of an ulcerated pilomatrixoma of the pinna in a middle-aged Caucasian female.Case presentationA 46-year-old Caucasian female presented with a one-month history of tender brownish lump on the pinna. Initially it was thought to represent a pyogenic granuloma. The lesion was treated by wide circular excision. Histopathological evaluation reported a benign calcifying epithelioma of Malherbe.ConclusionA search of the world’s literature has led us to believe that this is a rare case of a calcifying epithelioma of Malherbe of the pinna. The rapid growth and ulcerative nature of this tumour makes this case even more unique.

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Aggressive Pilomatricoma in Childhood

Cited by 16 publications

References 0 publications

Pilomatrix Carcinoma

Pilomatrix Carcinoma

Pilomatrixoma: A Diagnostic Pitfall in Fine Needle Aspiration Cytology

A patient with ulcerated calcifying epithelioma of Malherbe in the pinna: case report

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