Aggressive primary mediastinal non‐Hodgkin′s lymphomas: a study of 29 cases

Abstract

Aggressive primary mediastinal non-Hodgkin's lymphomas (NHL) represent a particular entity among intrathoracic neoplasms. Twenty-nine patients with primary mediastinal aggressive NHL diagnosed and treated in the author's institution were studied.According to the Revised European-American Lymphoma (REAL) classification, there were 15 diffuse large B-cell, eight T-lymphoblastic, four anaplastic, one large Tcell and one Burkitt's lymphomas. The study group consisted of 14 females and 15 males, with a mean age of 38 yrs. Symptoms arose from an aggressive anterior mediastinal mass, with a high prevalence of superior vena caval syndrome, pleural, and pericardial effusions. At the time of diagnosis, disease was confined to supradiaphragmatic areas in 24 patients, while subdiaphragmatic nodal or extranodal involvement was also present in five.All patients received a combination of aggressive chemotherapy regimens, mainly according to the French protocols for the treatment of NHL. A chest radiograph response of <50% after the first course of chemotherapy and failure to achieve a complete remission after the first line of chemotherapy were significantly associated with unfavourable prognosis. Overall 5-yr and 9-yr survival rates were 55 and 48%, respectively.Patients properly diagnosed and treated with a combined modality of chemotherapy can experience prolonged survival.

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“…In our finding chest wall deformity was 36.84 % but in France it was only 2%. 32 Others less common findings of our study were limb weakness, features of hypothyroidism, lung collapse, hemoptysis, B-Symptoms, superior vena cava syndrome (SVCs).…”

Massive Pericardial Effusion as The First Manifestation of Childhood Non-Hodgkin’s Lymphoma: A Case Report

“…It demonstrates tumour bulk and pleural effusion. Chest computed tomography (CT) scans are examined for precise tumour location, presence of necrosis, pulmonary parenchymal involvement, chest wall invasion, and more assessment of pleuropericardial effusion (14,15). Definitive diagnosis is achieved via biopsy and histopathological examination, and treatment begins after complete staging according to Ann Arbor classification.…”

Massive pericardial effusion as the first manifestation of childhood non‐Hodgkin's lymphoma: A case report

“…It demonstrates tumor bulk and pleural effusion. Chest computed tomography (CT) scans are examined for precise tumor location, presence of necrosis, pulmonary parenchymal involvement, chest wall invasion, and more assessment of pleuropericardial 17,18 Definitive diagnosis is achieved via biopsy and histopathological examination, and treatment begins after complete staging according to Ann Arbor classification.…”