Aggressive Resection of Malignant Paraaortic and Pelvic Tumors Accompanied by Arterial Reconstruction with Synthetic Arterial Graft

Tani, Ryotaro; Hori, Tomohide; Yamamoto, Hidekazu; Harada, Hideki; Yamamoto, Masafumi; Yamada, Masahiro; Yazawa, Takefumi; Sasaki, Ben; Tani, Masaki; Asahi, Satoru; Katsura, Hikotaro; Kamada, Yasuyuki; Aoyama, Ryuhei; Sasaki, Y.; Zaima, Masazumi

doi:10.12659/ajcr.931569

Cited by 4 publications

(1 citation statement)

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“…Further studies to confirm the value of carboplatin/anthracyclines as the optimal adjuvant chemotherapy must be performed. A case report mentioned one particular patient with advanced OCS who underwent neoadjuvant chemotherapy (NACT), followed by non-curative unilateral resection of the appendicular organ, total omentectomy, and adjuvant chemotherapy [ 60 ]. She experienced recurrence roughly 21 months after this initial surgery and received aggressive tumour resection of the para-aortic and/or pelvic tumours, and replacement of the abdominal aorta and/or iliac arteries with a synthetic arterial graft.…”

Section: Introductionmentioning

confidence: 99%

Frontiers of Ovarian Carcinosarcoma

Ismail,

Choi,

Boussios

2023

Curr. Treat. Options in Oncol.

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Opinion statementOvarian carcinosarcoma (OCS), also known as a malignant mixed Müllerian tumour (MMMT), is a rare and aggressive form of cancer that accounts for less than 5% of ovarian cancers. It is characterized by high morbidity and mortality rates, with a median overall survival (OS) of less than 2 years. Several factors, including advancing age, nulliparity, reduced lactation rates, decreased use of oral contraceptive pills, genetic mutations in BRCA (breast cancer) genes, and the use of assisted reproductive technology, may increase the risk of OCS. Poor prognostic factors include an advanced stage at diagnosis, older age, lymph node metastasis, suboptimal surgical cytoreduction, the presence of heterologous features on histopathology, and increased expression of vascular endothelial growth factor (VEGF), tumour protein p53, and p53 alongside Wilms tumour 1 (WT1). The main treatment approach for OCS is cytoreductive surgery followed by platinum-based chemotherapy, although immunotherapy is showing promise. Homologous recombination deficiency (HRD) testing may enhance outcomes by enabling personalized immunotherapy and targeted therapies for specific patient groups, thereby reducing unnecessary side effects and healthcare costs. However, there is currently a lack of standardised treatment regimens for OCS patients, with most studies consisting of case reports and a shortage of suitable comparator groups. This article aims to provide clinicians with information on the epidemiology, risk factors, prognostic factors, and latest therapeutic advancements in OCS.

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Section: Introductionmentioning

confidence: 99%