Aggressive Surgery Improves Long-term Survival in Neuroendocrine Pancreatic Tumors

Abstract

Organ-preserving resections offer sufficient local control in LGC; therefore, radical resections do not seem to be justified. On the other hand, radical resection is indicated even in metastasized patients or in case of loco-regional recurrence. The silent and slow course of the disease facilitates long-term surgical control.

Neuroendocrine Tumors of the Pancreas

“…A prognostic score that incorporated age, histological grading, and the presence or absence of distant metastases significantly predicted long-term survival outcome. That study [83] could not reproduce tumor size or nodal status as independent predictors of poor long-term survival outcome, as reported by earlier smaller multivariate analyses [76,84]. Because the U.S. national cancer database captures only malignant PNETs, this result might be biased by the selection of larger tumors (81% of analyzed tumors were Ͼ2 cm).…”

Are There Prognostic Factors Related to Recurrence in Pancreatic Endocrine Tumors?

“…Other authors have reported prognostic factors predicting survival after the resection of PETs [7,8,9,10]. To our knowledge, prognostic factors related to the risk of recurrence in PETs have rarely been reported in the literature [11,12,13,14]. …”

GEP–NETS UPDATE: A review on surgery of gastro-entero-pancreatic neuroendocrine tumors

“…As most of NETs have a low aggressive behavior, a tendency to promote aggressive surgery, even in the presence of LM, exists. Generally, when R0 resection is achievable, an aggressive approach for well-differentiated NETs, possibly with a Ki67 !10%, is widely used (44,45,46). Some patients present with locally advanced tumors with local infiltration of the portal vein or stomach.…”