Aggressive Thyroid Gland Carcinoma: A Case Series

Dworkin-Valenti, JP

doi:10.17352/2455-1759.000064

Cited by 2 publications

(4 citation statements)

References 50 publications

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“…We report a case of a patient with a collision tumor containing widely invasive OC, classical and hobnail variants of PTC, and areas with PDTC. Collision tumors can contain components with different aggressiveness, treatments, and prognosis, challenging their management ( 24 ). Widely invasive OC, HPTC, and PDTC are some of the thyroid cancers that are considered to have a worse prognosis among DTC ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

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Thyroid collision tumor containing oncocytic carcinoma, classical and hobnail variants of papillary carcinoma and areas of poorly differentiated carcinoma

Toyoshima

Domingues

Soares

et al. 2021

Archives of Endocrinology and Metabolism

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Collision tumors are rare and may comprise components with different behavior, treatments, and prognosis. We report an unprecedented case of aggressive thyroid collision tumor containing widely invasive oncocytic carcinoma (OC), classical and hobnail (HPTC) variants of papillary carcinoma, and poorly differentiated carcinoma (PDTC). The patient underwent total thyroidectomy, radioactive iodine therapy, and within months progressed with local recurrence, and pulmonary metastases requiring neck dissection, external radiotherapy and systemic treatment with sorafenib. The rapid progression, dedifferentiated metastatic lesions, and failure to treatments resulted in the patient´s death. The great variety of histological types and the evolution of this case were a challenge for the management of metastatic disease. Widely invasive OC, HPTC and PDTC are considered to have a worse prognosis. HPTC has never been reported as a component of a collision tumor. HPTC and PDTC should call attention to a possible higher-grade transformation.

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Section: Discussionmentioning

confidence: 99%

“…PDTC is associated with an increased risk of metastasis and tumor-related death ( 3 , 15 ). The presence of PDTC in the collision tumor is a sign of aggressiveness, poor prognosis and likely transformation of the more differentiated PTC ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Thyroid collision tumor containing oncocytic carcinoma, classical and hobnail variants of papillary carcinoma and areas of poorly differentiated carcinoma

Toyoshima

Domingues

Soares

et al. 2021

Archives of Endocrinology and Metabolism

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“…FTCs are malignant epithelial tumors that show evidence of follicular cell differentiation but lack the diagnostic nuclear features of PTCs (1,2). Both are well-differentiated thyroid carcinomas (WDTC), FTC typically being more aggressive with a female-to-male incidence ratio of 4:1 and more likely to show distant metastasis compared to PTC (3). The incidence of distant metastasis in FTC has been reported to be 6-20%, with the bones and lungs being the most common locations (4).…”

Section: Introductionmentioning

confidence: 99%

“…Long bones, such as the femur and flat bones, particularly the pelvis and sternum, are more frequently involved in bone metastases from FTC, whereas the ribs, vertebrae and sternum are the bones most frequently involved in PTC (3,4). Skull metastases from both FTC and PTC are extremely rare, accounting for only 2.5% of all bone metastases, the majority of skull metastases are from FTC, followed by PTC (5,6).…”

Section: Introductionmentioning

confidence: 99%

Follicular Thyroid Carcinoma Metastasis to the Skull and Brain: Case Series with Literature Review

Bailey¹,

Ali²,

Ferdous³

et al. 2023

Bangladesh J. Nuclear Med.

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Distant metastasis is more common in follicular thyroid carcinomas (FTC) than papillary thyroid carcinomas (PTC), as vascular invasion is often characteristic of FTC. Lung, bone, brain, liver, bladder, and skin are potential sites of distant metastases. On the other hand, lymph node involvement is much less common (8–10%) in cases of FTC compared to PTC. The therapy of patients may be significantly impacted by learning more about the epidemiological features of thyroid metastases at uncommon sites. In our experience, metastases in uncommon sites do not always indicate a poor prognosis for differentiated thyroid carcinoma (DTC), which might be due to the disease patterns. Every year, around 5% new FTC patients are registered, treated with radioiodine, and followed up in the thyroid division of National Institute of Nuclear Medicine and Allied Sciences (NINMAS). Four FTC patients (F=3, M=1) with skull bone and brain metastases are discussed in this case series. All of them were post thyroidectomized and were referred to NINMAS for radioiodine ablation therapy (RAIT). Two of them had skull and brain metastases, third patient had extensive skull, facial bone and pubic bone invasion, whereas, fourth patient had multiple skull metastases. Bangladesh J. Nuclear Med. 25(2): 128-137, 2022

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Aggressive Thyroid Gland Carcinoma: A Case Series

Cited by 2 publications

References 50 publications

Thyroid collision tumor containing oncocytic carcinoma, classical and hobnail variants of papillary carcinoma and areas of poorly differentiated carcinoma

Thyroid collision tumor containing oncocytic carcinoma, classical and hobnail variants of papillary carcinoma and areas of poorly differentiated carcinoma

Follicular Thyroid Carcinoma Metastasis to the Skull and Brain: Case Series with Literature Review

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