Aggressive undifferentiated pleomorphic sarcoma of the stomach involving long-term survival: A case report and literature review

Abstract

Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital.Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. An endoscopic ultrasound-guided fine-needle biopsy examination of the gastric tumor revealed features of pleomorphic sarcoma and high-grade spindle-shaped cells. Total gastrectomy was performed on the primary tumor, together with combined resection of the small intestine for the metastatic tumors. However, the tumor recurred in the mesentery of the sigmoid colon 6 months after the operation. A second operation was performed to resect the recurrent tumor. Since the second surgical procedure, the patient has remained free from recurrence for >7 years. Although the prognosis of abdominal UPS was considered to be poor, even after curative surgery, the present case experienced a long-term survival of gastric UPS after undergoing surgical resection alone.

Pleomorphic sarcoma of the jejunum: Case report

“…Undifferentiated pleomorphic sarcoma (UPS), which was formerly known as malignant fibrous histiocytoma, is a high-grade sarcoma, which mainly arises from the soft tissue of the extremities and can appear at any age 8 . UPS is the most common type of high-grade malignant sarcoma found in elderly people and most are asymptomatic 8 .…”

Surgical Resection of Undifferentiated Pleomorphic Sarcoma (UPS) With Jejunal Perforation, A Suspected Case of Metastasis of Lung Cancer: A Case Report

“…There have been only a few cases of UPS in the gastrointestinal tract according to the diagnostic criteria after the WHO 2013 reclassi cation [4][5][6][7][8][9][10][11], and this is the second case with perforation of the gastrointestinal tract [4]. UPS lacks characteristic physical symptoms and imaging ndings.…”

Surgical resection of undifferentiated pleomorphic sarcoma (UPS) with jejunal perforation, a suspected case of metastasis of lung cancer

“…As UPS/MFH progresses, it mainly spreads to the lungs (82%), lymph nodes (32%), liver (15%) and bones (11%), but rarely to the small intestine or colon. [2] There have been only a few cases of UPS in the gastrointestinal tract according to the diagnostic criteria after the WHO 2013 reclassification [4][5][6][7][8][9][10][11][12] and this is the second case with perforation of the gastrointestinal tract [4]. UPS lacks characteristic physical symptoms and imaging findings.…”