Aggressiveness of 4T1 breast cancer cells hampered by Wnt production-2 inhibitor nanoparticles: An in vitro study

Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells

“…Suppression of βcatenin or WNT blocked cancer cell proliferation in animal models [ 35 ]. LGK974 and IWP that block WNT secretion reduced tumor size in head and neck cancer animal models and suppressed the migration capability of breast cancer cell lines, respectively [ 36 , 37 ]. Moreover, OMP18R5 is a monoclonal antibody that targets FZD-inhibited tumor growth in animal models [ 38 ].…”

Wnt Signaling in the Development of Bone Metastasis

“…This may be achieved by the activation of autocrine transcription within cancer cells and/or by paracrine stimulation from cells in the bone microenvironment that promote cell cycle pathways [ 112 ]. To date, the precise interactions and molecules that are involved in the process, however, are poorly understood [ 122 ]. The stem cell niche was identified as playing an important role in the reactivation of cancer cells.…”

Rational Formulation of targeted ABT-737 nanoparticles by self-assembled polypeptides and designed peptides

“…The group of Kelley developed mitochondria-penetrating peptides composed of alternating positively charged and hydrophobic residues that crossed the mitochondrial membranes [ 33 ]. Our group developed a mitochondria-targeted NPs system, that is based on a coassembly of two components, an anionic po lypeptide with an amphiphilic and an oppositely charged designed p eptide, denoted PoP-NPs [ [34] , [35] , [36] , [37] , [38] ]. Poly gamma glutamic acid (ϒPGA) is a biodegradable, non-toxic, non-immunogenic, biopolymer which has been shown to form NPs when combined with positively charged polymers.…”

“…[ 39 , 40 ], The PoP-NPs are generated by a sequence of mixing steps that combine ϒPGA with the designed amphiphilic and cationic β-sheet peptide, Pro-Lys-(Phe-Lys)5-Pro (PFK) [ 34 ]. PFK peptide, with its repeat of hydrophilic and hydrophobic amino acids, induces folding into β-sheet conformation and organizes into positively charged bilayer-fibrils under certain concentrations, pH, and electrostatic screening conditions [ [34] , [35] , [36] , [37] , [38] , 41 ]. The fibrils of PFK [ [42] , [43] , [44] , [45] ] in the NPs point their Phe side chains into the fibrils’ interior, and their Lys residues to the surrounding anionic ϒPGA.…”

“…These LND-PoP-NPs led to tumor growth inhibition with no adverse side effects, upon intravenous administration in an MDA-MB-231 xenograft breast cancer murine model. The formulations of PoP-NPs were also adjusted to the IWP -2, a WNT inhibitor small molecule [ 37 ] and to the delivery of oligonucleotides [ 46 ].…”