Aging affects initiation and continuation of T cell proliferation

Jiang, Jiu; Gross, D. J.; Elbaum, Philip; Murasko, Donna M.

doi:10.1016/j.mad.2007.02.002

Cited by 47 publications

(41 citation statements)

References 27 publications

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“…The reasons for this are not clear, but could be partly due to the potential inhibitory effect of CD4 + CD25 + T cells on T cell proliferation (Ge et al, 2002). Decreased proliferation of T cells is a common feature of ageing and involves both a lower percentage of proliferating cells and fewer rounds of division (Jiang et al, 2007). Importantly, it has been demonstrated that cytokine production by PBMC or T cell subsets from aged donors is unimpaired, or even increased, and yet proliferation in response to a mitogen is severely impaired, suggesting different signalling pathways may regulate the age-associated change on T cell activation/cytokine production and proliferation in response to antigen (Tortorella et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Probiotic modulation of dendritic cell function is influenced by ageing

et al. 2014

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Dendritic cells (DCs) are critical for the generation of T-cell responses. DC function may be modulated by probiotics, which confer health benefits in immunocompromised individuals, such as the elderly. This study investigated the effects of four probiotics, Bifidobacterium longum bv. infantis CCUG 52486, B. longum SP 07/3, Lactobacillus rhamnosus GG (L.GG) and L. casei Shirota (LcS), on DC function in an allogeneic mixed leucocyte reaction (MLR) model, using DCs and T-cells from young and older donors in different combinations. All four probiotics enhanced expression of CD40, CD80 and CCR7 on both young and older DCs, but enhanced cytokine production (TGF-β, TNF-α) by old DCs only. LcS induced IL-12 and IFNγ production by DC to a greater degree than other strains, while B. longum bv. infantis CCUG 52486 favoured IL-10 production. Stimulation of young T cells in an allogeneic MLR with DC was enhanced by probiotic pretreatment of old DCs, which demonstrated greater activation (CD25) than untreated controls. However, pretreatment of young or old DCs with LPS or probiotics failed to enhance the proliferation of T-cells derived from older donors. In conclusion, this study demonstrates that ageing increases the responsiveness of DCs to probiotics, but this is not sufficient to overcome the impact of immunosenescence in the MLR.

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Section: Discussionmentioning

confidence: 99%

Probiotic modulation of dendritic cell function is influenced by ageing

et al. 2014

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“…HVEM on Tregs and BTLA on effector T cells allow for their interactions (35) and again gD would be expected to block Treg-mediated suppression through direct cell to cell contact. The role of CD160 in regulation of CD8 + T cell differentiation is not well characterized but available studies suggest that it plays an immunoinhibitory role (28) and that is becomes upregulated on CD8 + T cells that progress toward exhaustion (60).…”

Section: Discussionmentioning

confidence: 99%

Augmentation of Primary Influenza A Virus-Specific CD8+ T Cell Responses in Aged Mice through Blockade of an Immunoinhibitory Pathway

DiMenna

Latimer

Parzych

et al. 2010

The Journal of Immunology

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Immune responses diminish with age resulting in an increased susceptibility of the elderly to infectious agents and an inability to mount protective immune responses to vaccines. Immunosenescence affects multiple aspects of the immune system, including CD8+ T cells, which control viral infections and are assumed to prevent the development of cancers. In this study, we tested if CD8+ T cell responses in aged mice could be enhanced through a vaccine that concomitantly expresses Ag and a molecule that blocks an immunoinhibitory pathway. Specifically, we tested a vaccine based on a replication-defective chimpanzee-derived adenovirus vector expressing the nucleoprotein (NP) of influenza A virus as a fusion protein with the HSV type 1 glycoprotein D, which through binding to the herpes virus entry mediator, blocks the immunoinhibitory herpes virus entry mediator B and T lymphocyte attenuator/CD160 pathways. Our results show that the vaccine expressing a fusion protein of NP and glycoprotein D induces significantly higher NP-specific CD8+ T cell responses in young and aged mice compared with the vaccine expressing NP only.

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“…For instance T-cells isolated from aged mice have slower kinetics and decreased proliferation following stimulation with the T-cell mitogen Concanavalin A (Con A) (Jiang et al 2007). In addition, clonal expansion of CD8 + T-cells in aged mice was reduced after exposure to influenza virus compared to adults.…”

Section: Age-related Changes In Peripheral Adaptive and Innate Immunitymentioning

confidence: 99%

Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

Corona

Fenn

Godbout

2011

J Neuroimmune Pharmacol

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A hallmark of the aged immune system is impaired immunoregulation of the innate and adaptive immune system in the periphery and also in the central nervous system (CNS). Impaired immunoregulation may predispose older individuals to an increased frequency of peripheral infections with concomitant cognitive and behavioral complications. Thus, normal aging is hypothesized to alter the highly coordinated interactions between the immune system and the brain. In support of this notion, mounting evidence in rodent models indicate that the increased inflammatory status of the brain is associated with increased reactivity of microglia, the innate immune cells of the CNS. Understanding how immunity is affected with age is important because CNS immune cells play an integral role in propagating inflammatory signals that are initiated in the periphery. Increased reactivity of microglia sets the stage for an exaggerated inflammatory cytokine response following activation of the peripheral innate immune system that is paralleled by prolonged sickness, depressive-like complications and cognitive impairment. Moreover, amplified neuroinflammation negatively affects several aspects of neural plasticity (e.g., neurogenesis, long-term potentiation, and dendritic morphology) that can contribute to the severity of neurological complications. The purpose of this review is to discuss several key peripheral and central immune changes that impair the coordinated response between the immune system and the brain and result in behavioral and cognitive deficits.

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Aging affects initiation and continuation of T cell proliferation

Cited by 47 publications

References 27 publications

Probiotic modulation of dendritic cell function is influenced by ageing

Probiotic modulation of dendritic cell function is influenced by ageing

Augmentation of Primary Influenza A Virus-Specific CD8+ T Cell Responses in Aged Mice through Blockade of an Immunoinhibitory Pathway

Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

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